Results 21 to 30 of about 5,184,526 (265)

Role of IL‐37‐ and IL‐37‐Treated Dendritic Cells in Acute Coronary Syndrome

Oxidative Medicine and Cellular Longevity, 2021
As a chronic inflammatory disease, atherosclerosis is a leading cause of morbidity and mortality in most countries. Inflammation is responsible for plaque instability and the subsequent onset of acute coronary syndrome (ACS), which is one of the leading causes of hospitalization.
Ruirui Zhu, Fangyuan Zhang, Chengliang Pan, Kunwu Yu, Yucheng Zhong, Qiutang Zeng   +5 more
openaire   +3 more sources

Pivotal Role of Serum IL-37 In Patients with Chronic HBV and HCV

Al-Mustansiriyah Journal of Science, 2023
Interleukin-37 (IL-37) is an anti-inflammatory cytokine that has an intrinsic role in many diseases through its extracellular and intracellular mechanisms. It was found to be in high concentrations in chronic diseases.
Ellaf Abdulljabbar Al-Jaryan, Luma Ghaeb Alsaadi, Alia Essam Alubadi, Majida Ghazi Magtooph   +3 more
doaj   +1 more source

Clinical Implications of IL-32, IL-34 and IL-37 in Atherosclerosis: Speculative Role in Cardiovascular Manifestations of COVID-19

Frontiers in Cardiovascular Medicine, 2021
Atherosclerosis, which is a primary cause of cardiovascular disease (CVD) deaths around the world, is a chronic inflammatory disease that is characterised by the accumulation of lipid plaques in the arterial wall, triggering inflammation that is ...
Ching Chee Law, Rajesh Puranik, Jingchun Fan, Jian Fei, Brett D. Hambly, Shisan Bao   +5 more
doaj   +1 more source

IL-37- and IL-35/IL-37-Producing Plasma Cells in Chronic Periodontitis [PDF]

Journal of Dental Research, 2019
Periodontitis is one of the most prevalent chronic inflammatory diseases and is induced by the interaction between oral microorganisms and the host immune system. Plasma cells are of special interest in chronic periodontitis (CP), as they represent ~50% of infiltrated immune cells in periodontal lesions. Plasma cells constitute the
L, Jing, S, Kim, L, Sun, L, Wang, E, Mildner, K, Divaris, Y, Jiao, S, Offenbacher   +7 more
openaire   +2 more sources

Aberrant Expression of Three New Members of IL-1 Family (IL-36α, IL-37 and IL-38) in Patients with Multiple Sclerosis [PDF]

Journal of Advanced Biomedical Sciences, 2023
Background & Objective: Multiple sclerosis (MS) is a neurodegenerative disease that is characterized by demyelination and neuronal dysfunction. The study of the expression of cytokine genes seems to be an appropriate option for assessing their potential ...
Forouzan Ahmadi Khoei, Somayeh Reiisi, Parisa Mohammadinejad   +2 more
doaj  

IL-37 is a fundamental inhibitor of innate immunity [PDF]

Nature Immunology, 2010
The function of interleukin 37 (IL-37; formerly IL-1 family member 7) has remained elusive. Expression of IL-37 in macrophages or epithelial cells almost completely suppressed production of pro-inflammatory cytokines, whereas the abundance of these cytokines increased with silencing of endogenous IL-37 in human blood cells.
Marcel F, Nold, Claudia A, Nold-Petry, Jarod A, Zepp, Brent E, Palmer, Philip, Bufler, Charles A, Dinarello   +5 more
openaire   +2 more sources

MiR-300 promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis by targeting IL-37

Autoimmunity, 2022
Background Fibroblast-like synoviocytes (FLS) are crucial regulators in the pathogenesis of rheumatoid arthritis (RA). Reportedly, microRNA (miR) participates in regulating the pathogenesis of RA.
Ying Wang, Ge Zhang, Wei Huang
doaj   +1 more source

Current Understanding of IL-37 in Human Health and Disease [PDF]

Frontiers in Immunology, 2021
IL-37 is a recently discovered cytokine in the IL-1 family exerting broad protective effects on inflammatory diseases, autoimmune diseases, and cancer. Immune and non-immune cells produce the IL-37 precursor upon pro-inflammatory stimuli. Intracellularly, caspase-1 cleaves and activates IL-37, and its mature form binds to Smad3; this complex ...
Zhangci Su, Zhangci Su, Zhangci Su, Xiaoan Tao, Xiaoan Tao, Xiaoan Tao   +5 more
openaire   +3 more sources

Potential role of IL-37 in atherosclerosis

Cytokine, 2019
IL-37 is a member of the IL-1 family, but unlike most other members of this family of cytokines, it has wide-ranging anti-inflammatory properties. Initially shown to bind IL-18 binding protein and prevent IL-18-mediated inflammation, its known role has been expanded to include distinct pathways, both intracellular involving the transcription factor ...
McCurdy S., Liu C., Yap J., Boisvert W.
openaire   +3 more sources

IL-27 regulates IL-18 binding protein in skin resident cells [PDF]

, 2012
IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased ...
Wittmann, M, Miriam Wittmann, Werfel, Thomas, Bachmann, M, Doble, Rosella, Muehl, H, Thomas Werfel, Doble Rosella, Pfeilschifter, Josef (Prof. Dr.), Doble, R, Heiko Mühl, Mühl Heiko, Malte Bachmann, Wittmann Miriam, Pfeilschifter, J, Wittmann, Miriam, Bachmann Malte, Werfel, T, Josef Pfeilschifter, Werfel Thomas, Bachmann, Malte, Mühl, Heiko, Rosella Doble, Pfeilschifter Josef   +23 more
core   +1 more source