Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review [PDF]
Journal of Inflammation ResearchYuan Xu, Jing-Yan Wang, Yang Zou, Xue-Wei Ma, Tian Meng College of Health Industry, Sichuan Tourism University, Chengdu, Sichuan, 610100, People’s Republic of ChinaCorrespondence: Yuan Xu, Email 230973159@qq.comAbstract: Inflammatory cytokines ...
Xu Y, Wang JY, Zou Y, Ma XW, Meng T
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Evaluating Serum Levels of IL-33, IL-36, IL-37 and Gene Expression of IL-37 in Patients with Psoriasis Vulgaris [PDF]
Iranian Journal of Allergy, Asthma and Immunology, 2018 Serum levels of interleukin (IL)-33, IL-36 and IL-37 have been reported to be up-regulated in various T helper (Th)1/Th17 mediated autoimmune/inflammatory diseases.
Mojtaba Sehat +4 more
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Parsing the IL-37-Mediated Suppression of Inflammasome Function [PDF]
Cells, 2020 Interleukin (IL)-37 is a member of the IL-1 family of cytokines. Although its broad anti-inflammatory properties are well described, the effects of IL-37 on inflammasome function remain poorly understood. Performing gene expression analyses, ASC oligomerization/speck assays and caspase-1 assays in bone marrow-derived macrophages (BMDM), and employing ...
Ina Rudloff +9 more
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Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance IL-37 exerts broad inhibitory properties on the innate inflammatory and acquired immune responses. We mutated the caspase-1 site in IL-37 and show that caspase-1 processing is required for maturation of the intracellular IL-37 precursor for its translocation to the nucleus.
Bulau, A.M. +11 more
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IL-37 Expression Is Downregulated in Lesional Psoriasis Skin [PDF]
ImmunoHorizons, 2020 Abstract IL-37 broadly suppresses inflammation in various disease models. However, studies of the regulation and role of IL-37 in psoriasis are limited and contradictive. Using transcriptome analysis, PCR, protein determination, and immunofluorescence, we demonstrated marked downregulation of IL-37 in biopsies from human lesional ...
Rønholt, K. +8 more
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The role of IL-36 and 37 in hepatocellular carcinoma [PDF]
Frontiers in ImmunologyHepatocellular carcinoma (HCC) has garnered considerable attention due to its morbidity and mortality. Although the precise mechanisms underlying HCC tumorigenesis remain to be elucidated, evidence suggests that host immunity plays a pivotal role in its ...
Juan Cao +7 more
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The anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response [PDF]
OncoImmunologyIL-37 is a member of the IL-1 superfamily exerting anti-inflammatory functions in a number of diseases. Extracellular IL-37 triggers the inhibitory receptor IL-1R8 that is known to regulate different NK cell pathways and functional activities including ...
Nadine Landolina +8 more
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IL-37 and IL-36 Cytokine Profiles in Chronic Hepatitis Delta During Bulevirtide Therapy [PDF]
PathogensChronic hepatitis delta is the most severe form of viral hepatitis and is associated with rapid progression to cirrhosis and hepatocellular carcinoma. Although bulevirtide (BLV) effectively inhibits hepatitis D virus (HDV) entry, immunological biomarkers
Verdiana Zulian +6 more
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The significant role of IL-15, IL-22, IL-37, and caspase 9 in polycystic ovary syndrome: A case-control study in a sample of Iraqi women [PDF]
Journal of Genetic Engineering and BiotechnologyThe study aims to evaluate the significant role of interleukin 15 (IL-15), IL-22, IL-37, and Caspase 9 gene expression in polycystic ovary syndrome (PCOS), focusing on the underlying mechanisms and potential diagnostic or therapeutic implications ...
Noor A. Mohammed +4 more
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Elevated IL-37 Serum Levels in Patients with Transitional Cell Carcinoma of Bladder [PDF]
Iranian Journal of Immunology, 2021 Background: Interleukin-37 (IL-37) is a recently described cytokine that emerges as a natural inhibitor of inflammatory and immune responses. However, IL-37 has not yet been investigated in bladder cancer, and its biological role is unknown.
Mohammad Reza Haghshenas +5 more
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