Results 121 to 130 of about 1,127 (146)

The role of NK cells in regulating tumorimmunity: current state, challenges and future strategies. [PDF]

Cancer Cell Int
Zhu W, Fan C, Zhao Y, Li W, Niu J, Dong S, Yang Z, Zhou W.   +7 more
europepmc   +1 more source

Interleukin-37 Ameliorates Articular Cartilage Damage in Two Murine Models of Osteoarthritis. [PDF]

Cartilage
van Geffen EW, van Beuningen HM, Aarts J, Vitters EL, Rijnen WHC, Blom AB, van de Loo FAJ, Blaney Davidson EN, Koenders MI, van Caam APM, van der Kraan PM.   +10 more
europepmc   +1 more source

Sex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice. [PDF]

Cells
Li Y, Zhang B, Yang Y, Su P, Samsom JN, Wong AHC, Liu F.   +6 more
europepmc   +1 more source

Strategies for the Development of NK Cell-Based Therapies for Cancer Treatment. [PDF]

Cells
Budagova T, Efremova A, Maiak M, Goldshtein D.   +3 more
europepmc   +1 more source

HPV-driven inflammatory pathways in ovarian carcinogenesis: molecular mechanisms and emerging therapeutic interventions. [PDF]

J Ovarian Res
Kermanshahi AZ, Ebrahimi F, Taherpoor A, Kazemi EK, Nahand JS, Poortahmasebi V, Jafari-Sales A, Bannazadeh Baghi H.   +7 more
europepmc   +1 more source

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IL-37 Attenuates Platelet Activation and Thrombosis Through IL-1R8 Pathway

Circulation Research, 2023
Background: IL-37 (interleukin-37), a natural suppressor of innate inflammatory and immune responses, is increased in patients with myocardial infarction. Platelets play an important role in the progress of myocardial infarction, but the direct effects of IL-37 on platelet activation and thrombosis, as well as the underlying ...
Yufei Chen, Jin Hong, Haoxuan Zhong, Yikai Zhao, Jian Li, Wei Shen, Xinping Luo, Haiming Shi, Liang Hu, Junling Liu, Wen Gao   +10 more
openaire   +2 more sources

IL-37 alleviates intervertebral disc degeneration via the IL-1R8/NF-κB pathway

Osteoarthritis and Cartilage, 2023
Intervertebral disc degeneration (IDD) has been reported to be a major cause of low back pain (LBP). Interleukin (IL)-37 is an anti-inflammatory cytokine of the interleukin-1 family, which exerts salutary physiological effects. In this study, we assessed the protective effect of IL-37 on IDD progression and its underlying mechanisms.Immunofluorescence (
S. Li, X. Pan, Y. Wu, Y. Tu, W. Hong, J. Ren, J. Miao, T. Wang, W. Xia, J. Lu, J. Chen, X. Hu, Y. Lin, X. Zhang, X. Wang   +14 more
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IL-1R8 expression in DLBCL regulates NK cell recruitment and influences patient prognosis

Functional & Integrative Genomics, 2023
The precise biological function of Interleukin-1 receptor 8 (IL-1R8) in diffuse large B-cell lymphoma (DLBCL) is still not well understood. Our goal is to decipher the profile of IL-1R8 expression status in DLBCL and to explore how IL-1R8 is involved in DLBCL progression.
Min, Yu, Qian, Zhang, Luying, Wan, Shixuan, Wang, Lifang, Zou, Zhiwei, Chen, Fei, Li   +6 more
openaire   +2 more sources

Characterization of a long isoform of IL-1R8 (TIR8/SIGIRR)

European Cytokine Network, 2017
IL-1R8, also known as SIGIRR or TIR8, is a trans-membrane protein belonging to the IL-1 receptor family. The human gene includes ten exons, and alternative splicing can result in different isoforms. We, herein, characterized a longer isoform of IL-1R8 containing an in-frame additional sequence between the TIR domain and the C-terminal portion of the ...
Maria Giovanna, Vilia, Marta, Tocchetti, Eleonora, Fonte, Ilenia, Sana, Marta, Muzio   +4 more
openaire   +2 more sources