IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. [PDF]
Nature, 2017 Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct structural and functional characteristics, acting as a negative regulator of ILR ...
Molgora M +14 more
europepmc +13 more sources
Beyond Negative Regulation: IL-1R8 and IL-1R2 as Novel Immune Checkpoints. [PDF]
Eur J ImmunolSelf‐regulation of the IL‐1 system mediated by the negative regulatory receptors IL‐1R8 and IL‐1R2 results in tuning of inflammation and metabolic rewiring, as well as lymphoid or myeloid cell immune suppression. IL‐1R8 and IL‐1R2 are emerging as potential therapeutic targets to modulate immunopathology and re‐educate lymphoid or myeloid cells ...
Supino D, Garuti R, Garlanda C.
europepmc +3 more sources
Correction: IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway [PDF]
Cell Death and Disease, 2021 Chang Jia +10 more
doaj +4 more sources
Interleukin-37b Suppressed ILC2s in Children with Allergic Rhinitis
Mediators of Inflammation, 2023 Background. Interleukin-37b is a fundamental inhibitor of innate and acquired immunity. Type 2 innate lymphoid cells (ILC2s) can secret type 2 cytokines and regulate allergic rhinitis (AR). However, the role of IL-37b in ILC2s in children with AR was not
Qingxiang Zeng +7 more
doaj +2 more sources
Phylogeny and Differential Gene Expression Profile of IL-1R8 in Normal Dog Tissue [PDF]
, 2022 Interleukin-1 Receptor 8 (IL-1R8) is a transmembrane protein of the IL-1 receptor family and represents an important regulator of the balance of innate and inflammatory responses.
Bianchessi L. +4 more
core +3 more sources
IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells [PDF]
, 2018 IL-1R8 is an Interleukin-1 receptor family member that acts as a negative regulator of IL-1 family receptor and Toll-like receptor (TLR) signaling. Both murine and human NK cells express high levels of IL-1R8 but its functional role in this cell type has
Molgora, Martina
core +2 more sources
Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process [PDF]
Frontiers in Immunology, 2023 Interleukin-37 (IL-37) is a newly discovered member of IL-1 family. The cytokine was proved to have extensive protective effects in infectious diseases, allergic diseases, metabolic diseases, autoimmune diseases and tumors since its discovery.
Min Gu +10 more
doaj +2 more sources
The anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response [PDF]
OncoImmunologyIL-37 is a member of the IL-1 superfamily exerting anti-inflammatory functions in a number of diseases. Extracellular IL-37 triggers the inhibitory receptor IL-1R8 that is known to regulate different NK cell pathways and functional activities including ...
Nadine Landolina +8 more
doaj +2 more sources
The role of interleukin-37 and interleukin-38 in the development and remission of autism spectrum disorder: a comprehensive review of neuroinflammatory mechanisms and potential therapeutic implications [PDF]
Frontiers in ImmunologyAutism spectrum disorder (ASD) is a complicated neurodevelopmental syndrome characterized by abnormalities in social communication, lack of interests, and repetitive behaviors.
Zakeya Al Rasbi +7 more
doaj +2 more sources
IL-1 Family Members in Bone Sarcomas. [PDF]
Cells: IL-1 family members have multiple pleiotropic functions affecting various tissues and cells, including the regulation of the immune response, hematopoietic homeostasis, bone remodeling, neuronal physiology, and synaptic plasticity.
Landuzzi L +5 more
europepmc +3 more sources