Results 21 to 30 of about 1,127 (146)

Macrophage diversity in cancer dissemination and metastasis. [PDF]

Cell Mol Immunol
Invasion and metastasis are hallmarks of cancer. In addition to the well-recognized hematogenous and lymphatic pathways of metastasis, cancer cell dissemination can occur via the transcoelomic and perineural routes, which are typical of ovarian and ...
Mantovani A, Marchesi F, Di Mitri D, Garlanda C.   +3 more
europepmc   +4 more sources

IL-37b alleviates inflammation in the temporomandibular joint cartilage via IL-1R8 pathway. [PDF]

Cell Prolif, 2019
AbstractObjectivesInterleukin (IL)‐37 is a natural suppressor of innate inflammation. This study was conducted to explore the anti‐inflammatory effects of IL‐37 in temporomandibular joint (TMJ) inflammation.Materials and MethodsThe expression of IL‐37 in the TMJ was measured using ELISA and IHC. Human TMJ chondrocytes were treated with IL‐37b and IL‐1β,
Luo P, Feng C, Jiang C, Ren X, Gou L, Ji P, Xu J.   +6 more
europepmc   +4 more sources

The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ. [PDF]

Cell Mol Immunol, 2023
Cytokine storms are crucial in the development of various inflammatory diseases, including sepsis and autoimmune disorders. The immunosuppressive cytokine INTERLEUKIN (IL)-37 consists of five isoforms (IL-37a-e). We identified IL-37a as a nuclear cytokine for the first time. Compared to IL-37b, IL-37a demonstrated greater efficacy in protecting against
Wei R, Han X, Li M, Ji Y, Zhang L, Christodoulou MI, Hameed Aga NJ, Zhang C, Gao R, Liu J, Fu J, Lu G, Xiao X, Liu X, Yang PC, McInnes IB, Sun Y, Gao P, Qin C, Huang SK, Zhou Y, Xu D.   +21 more
europepmc   +3 more sources

High IL-1R8 expression in breast tumors promotes tumor growth and contributes to impaired antitumor immunity. [PDF]

Oncotarget, 2017
Tumors develop numerous strategies to fine-tune inflammation and avoid detection and eradication by the immune system. The identification of mechanisms leading to local immune dysregulation is critical to improve cancer therapy. We here demonstrate that Interleukin-1 receptor 8 (IL-1R8 - previously known as SIGIRR/TIR8), a negative regulator of Toll ...
Campesato LF, Silva APM, Cordeiro L, Correa BR, Navarro FCP, Zanin RF, Marçola M, Inoue LT, Duarte ML, Molgora M, Pasqualini F, Massara M, Galante P, Barroso-Sousa R, Polentarutti N, Riva F, Costa ET, Mantovani A, Garlanda C, Camargo AA.   +19 more
europepmc   +4 more sources

IL-37 suppresses CNS autoimmunity by increasing the frequency of Treg cells and reducing CD4 + T cell-derived IL-10 production. [PDF]

J Neuroinflammation
BACKGROUND: Interleukin-37 (IL-37) has anti-inflammatory properties in innate and adaptive immunity. Patients with multiple sclerosis (MS), an autoimmune inflammatory demyelinating disease of the central nervous system (CNS), have increased serum levels ...
Yazdani R, Naziri H, Azizi G, Ciric B, Askari M, Ahmadi AM, Aseervatham J, Zhang GX, Rostami A.   +8 more
europepmc   +3 more sources

Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8. [PDF]

Immunol Rev, 2018
SummaryInterleukin‐1 receptor family members (ILRs) and Toll‐Like Receptors (TLRs) are key players in immunity and inflammation and are tightly regulated at different levels. Most cell types, including cells of the innate and adaptive immune system express ILRs and TLRs.
Molgora M, Supino D, Mantovani A, Garlanda C.   +3 more
europepmc   +5 more sources

Potential Role of IL-37 in Atopic Dermatitis

Cells, 2023
Interleukin 37 (IL-37) is a recently discovered member of the IL-1 cytokine family that appears to have anti-inflammatory and immunosuppressive effects in various diseases.
Alicja Mesjasz, Magdalena Trzeciak, Jolanta Gleń, Marta Jaskulak   +3 more
doaj   +1 more source

IL-37 alleviates Coxsackievirus B3-induced viral myocarditis via inhibiting NLRP3 inflammasome-mediated pyroptosis

Scientific Reports, 2022
Our study aims to verify the potential effects and underlying mechanisms of IL-37 in Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC). VMC model was established by intraperitoneal injection of CVB3 into 6-week-old male balb-c mice on day 0.
Lin Sun, Haitao Yuan, Gang Zhao
doaj   +1 more source

Microenvironmental signals shaping NK‐cell reactivity in cancer

European Journal of Immunology, Volume 53, Issue 12, December 2023., 2023
Graphical Abstract: NK‐cell activity in the tumor microenvironment is intricately orchestrated by multiple factors in addition to activating and inhibitory receptor signaling. This review discusses the latest findings on microenvironmental sensors and key players regulating NK cells in cancer and highlights their potential applications in NK‐cell‐based
Bianca M. Balzasch, Adelheid Cerwenka
wiley   +1 more source

Spirocyclic Iodonium Ylides for Fluorine‐18 Radiolabeling of Non‐Activated Arenes: From Concept to Clinical Research

The Chemical Record, Volume 23, Issue 9, September 2023., 2023
Radiolabeling of electron‐rich (hetero)aromatic rings with fluorine‐18 has been a long‐standing challenge in the production of radiotracers for positron emission tomography. Nearly a decade after our original publication, we discuss the history and various applications of spirocyclic iodonium ylide (SCIDY) precursors for the incorporation of fluorine ...
Melissa Chassé, Anna Pees, Anton Lindberg, Steven H. Liang, Neil Vasdev   +4 more
wiley   +1 more source