Results 31 to 40 of about 1,127 (146)
Ecotoxicology and Environmental Safety, 2021 We have shown in the past studies that fine particulate matter (PM2.5) exposure increases airway hyperresponsiveness and leads to lung inflammation damage. Interleukin (IL)-37 plays a inhibitory role in inflammation activation and maintenance.
Min Wang +5 more
doaj +1 more source
The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity. [PDF]
, 2021 Summary Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections.
Alessandra Boletta +25 more
core +1 more source
Experimental Dermatology, Volume 32, Issue 7, Page 1120-1131, July 2023., 2023 Abstract Recent data indicate that distinct skin areas show different microbial/chemical milieu. Keratinocytes (KC) respond to these stimuli by producing cytokine mediators. Therefore, we aimed to determine KC‐derived cytokine expression in distinct healthy skin regions (gland‐poor [GP], sebaceous gland‐rich [SGR] and apocrine gland‐rich [AGR]), and ...
Lilla Szabó +10 more
wiley +1 more source
IL-1 Family Cytokines in Inflammatory Dermatoses : Pathogenetic Role and Potential Therapeutic Implications [PDF]
, 2022 The interleukin-1 (IL-1) family is involved in the correct functioning and regulation of the innate immune system, linking innate and adaptative immune responses.
Iznardo, Helena +2 more
core +1 more source
Liver Cancer International, Volume 4, Issue 1, Page 42-57, March 2023., 2023 The tumour microenvironment consists of a wide variety of different cell populations that show complex interactions with each other and the malignant tumour cells. In this review, we aim to discuss the current knowledge on the role of innate immune cells and stromal cell populations in HCC initiation and progression as well as related novel therapeutic
Charlotte Rennert +5 more
wiley +1 more source
Cell Death Discovery, 2022 White adipose tissue (WAT) homeostasis substantiated by type 2 immunity is indispensable to counteract obesity and metabolic disorders. IL-33/suppression of tumorigenicity (ST) 2 signaling promotes type 2 response in WAT, while potential regulators ...
Chaoze Li +15 more
doaj +1 more source
Journal of Immunology Research, Volume 2023, Issue 1, 2023., 2023 Human cytomegalovirus (HCMV) infection is globally distributed, and the liver is one of the major targeting organs. So far, the mechanisms for cell and organ damage have not fully been elucidated and the treatments for the infection are mainly at symptoms. IL‐37 has shown a protective role in certain inflammatory diseases.
Yufei Ruan +10 more
wiley +1 more source
Modulation of Liver Inflammation and Fibrosis by Interleukin-37 [PDF]
, 2021 Background and Aims: Chronic inflammation induces liver fibrosis, cirrhosis and potentially liver cancer. Kupffer cells modulate hepatic stellate cells by secreting immunologically active proteins as TGF-β.
Bufler, Philip +11 more
core +4 more sources
Current Understanding of IL-37 in Human Health and Disease
Frontiers in Immunology, 2021 IL-37 is a recently discovered cytokine in the IL-1 family exerting broad protective effects on inflammatory diseases, autoimmune diseases, and cancer. Immune and non-immune cells produce the IL-37 precursor upon pro-inflammatory stimuli. Intracellularly,
Zhangci Su +5 more
doaj +1 more source
Investigate the regulatory effect of human IL-37 isoform a (IL-37a) on Toll-like receptor (TLR) response in vitro and in vivo [PDF]
, 2020 Background: Interleukin-37 is a newly discovered member of the IL-1 superfamily, consisting of 5 isoforms (IL-37a-e) due to different RNA splicing.
Ji, Yuan
core +1 more source