Results 51 to 60 of about 1,127 (146)

IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILC

Seminars in Immunology, 2023
Interleukin-1 receptor family members (ILRs) and Toll-Like Receptors (TLRs) play pivotal role in immunity and inflammation and are expressed by most cell types including cells of both the innate and adaptive immune system. In this context, IL-1 superfamily members are also important players in regulating function and differentiation of adaptive and ...
Francesca R, Mariotti, Domenico, Supino, Nadine, Landolina, Cecilia, Garlanda, Alberto, Mantovani, Lorenzo, Moretta, Enrico, Maggi   +6 more
openaire   +2 more sources

Tuning inflammation in tuberculosis: the role of decoy receptors [PDF]

, 2009
Decoy receptors are "silent scavengers" of CC chemokines and cytokines, which play a key role in damping inflammation and tissue damage. In this review we discuss on recent findings demonstrating that these receptors set the balance between antimicrobial
Alfredo Salerno, Algood, Algood, Algood, Bean, Blackburn, Boule, Bozza, Chensue, Christensen, Di Liberto, Diana Di Liberto, Feng, Flynn, Francesco Dieli, Galliera, Garlanda, Garlanda, Garlanda, Giuliana Guggino, Graham, Guido Sireci, Kaufmann, Kipnis, Lau, Lech, Liu, Mantovani, Mantovani, Mantovani, Marco P. La Manna, Marshak-Rothstein, Martinez de la Torre, McKimmie, Miller, Nadia Caccamo, Nathan, Nibbs, Nibbs, Nibbs, Orme, Pawar, Peters, Polentarutti, Roach, Romani, Rossi, Rutledge, Scott, Seiler, Serena Meraviglia, Subramanian, Townson, Wald, Weber, Wu, Wu   +56 more
core   +1 more source

Cracking the Toll-like receptor code in fungal infections [PDF]

, 2010
Innate control of fungal infection requires the specific recognition of invariant fungal molecular structures by a variety of innate immune receptors, including Toll-like receptors.
Carvalho, Agostinho, Cunha, Cristina, Romani, Luigina   +2 more
core   +1 more source

New therapeutic concepts against ischemia-reperfusion injury in organ transplantation. [PDF]

, 2023
INTRODUCTION: Ischemia-reperfusion injury (IRI) involves a positive amplification feedback loop that stimulates innate immune-driven tissue damage associated with organ procurement from deceased donors and during transplantation surgery.
Cheng, Brian, Dery, Kenneth, Kupiec-Weglinski, Jerzy, Yao, Siyuan   +3 more
core   +1 more source

Characteristics and Functions of IL-37 [PDF]

International Journal of Biomedicine
Interleukin-37 (IL-37), previously known as IL-1F7, is a member of the IL-1 family of cytokines. There are five basic subtypes of IL-37, including IL-37a, IL-37b, IL-37c, IL-37d, and IL-37e.
Fang Yang, Li Gao, Xinya Wu, Xuan Su, Weijie Ma, Lei Zhong, Aihua Liu, Fukai Bao   +7 more
doaj   +1 more source

The potential of interleukin-37 as an effective therapeutic agent in asthma

Respiratory Research, 2017
Interleukin (IL)-37 belongs to the IL-1 cytokine family. It binds to IL-18Rα and recruits the orphan decoy IL-1R8. Emerging evidence shows that IL-37 is a key player in the regulation of inflammation, cellular differentiation, and proliferation.
Lina Zhang, Jie Zhang, Peng Gao
doaj   +1 more source

Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination [PDF]

, 2017
Toll-like receptors (TLRs) are the major pattern recognition receptors that mediate sensing of a wide range of microorganisms. TLR2 forms heterodimers with either TLR1 or TLR6, broadening its ligand diversity against pathogens.
Boualem Sendid, Daniel Poulain, Didier Le Roy, Hélène Vancraeyneste, Laura Choteau, Laurent Dubuquoy, Luiginia Romani, Samir Jawhara, Thierry Calandra, Thierry Jouault, Thierry Roger   +10 more
core   +3 more sources

Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR.

PLoS ONE, 2020
Chlamydia trachomatis is the most common bacterial sexually-transmitted infection and the major cause of preventable blindness worldwide. The asymptomatic nature of many infections along with uncontrolled inflammation leads to irreversible damage in the ...
Mufadhal Al-Kuhlani, Graham Lambert, Sukumar Pal, Luis de la Maza, David M Ojcius   +4 more
doaj   +1 more source

Activation of Mast Cells by Neuropeptides: The Role of Pro-Inflammatory and Anti-Inflammatory Cytokines [PDF]

, 2023
Mast cells (MCs) are tissue cells that are derived from bone marrow stem cells that contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity, autoimmunity, and mental disorders.
Ronconi, Gianpaolo
core   +1 more source

Expression and function of IL-1R8 (TIR8/SIGIRR), a regulatory member of the IL-1 receptor family in platelets [PDF]

Cardiovascular Research, 2016
Platelets express functional interleukin-1 receptor-1 (IL-1R1) as well as a repertoire of toll-like receptors (TLRs) involved in platelet activation, platelet-leucocyte reciprocal activation, and immunopathology. IL-1R8, also known as single Ig IL-1-related receptor (SIGIRR) or TIR8, is a member of the IL-1R family that negatively regulates responses ...
A. Anselmo, F. Riva, S. Gentile, C. Soldani, M. Barbagallo, C. Mazzon, F. Feruglio, N. Polentarutti, P. Somma, P. Carullo, C. Angelini, M. Bacci, G.L. Mendolicchio, A. Voza, M. Nebuloni, A. Mantovani, C. Garlanda   +16 more
openaire   +4 more sources