Soluble interleukin-1 receptor type 2 plasma levels in Parkinson’s disease: relationship with cardiac autonomic profile before and after peripheral mechanical somatosensory stimulation [PDF]
, 2023 Introduction: Systemic inflammation promotes neurodegeneration in Parkinson's disease (PD). Interleukin-1 receptor type 2 (sIL-1R2) plasma levels increase during inflammation.
A. Mantovani +11 more
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Alzheimer's &Dementia, Volume 21, Issue S3, December 2025.Abstract Background The APOE4 allele is a significant genetic risk factor for Alzheimer's disease (AD). Prior work from our group suggests that among neuropathologically verified AD patients, homozygous APOE4 status increases psychosis risk in females compared to heterozygotes, non‐carriers, and males but only in the presence of Lewy Body (LB ...
Gayathiri Rajkumar +10 more
wiley +1 more source
Herstellung und Charakterisierung monoklonaler Antikörper gegen das Toll-like-Interleukin-Rezeptor-Familienmitglied TIR8/SIGIRR [PDF]
, 2019 Wir stellten mehrere monoklonale Antikörper gegen murines TIR8/SIGIRR her und beschrieben den Isotyp, die Eigenschaften in der Zell-Kultur, im ELISA, sowie für einzelne Klone die Eigenschaften im Western-Blot.Wir zeigen Verbesserungs- und ...
Djoko Kamdem, Edgar
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Ionic Liquid Aided [11C]CO Fixation for Synthesis of 11C‐carbonyls
ChemistryOpen, Volume 14, Issue 7, July 2025.Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid used in a proof‐of‐concept study evaluating its utility to trap carbon‐11 (t1/2=20.4 min)‐labeled CO for preparation of amides, ureas and carbamates. Abstract Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid developed to capture CO and has shown ...
Anton Lindberg +5 more
wiley +1 more source
Characterization of SIGIRR/IL-1R8 Homolog from Zebrafish Provides New Insights into Its Inhibitory Role in Hepatic Inflammation [PDF]
The Journal of Immunology, 2016 Abstract Single Ig IL-1R–related molecule (SIGIRR, also called IL-1R8 or Toll/IL-1R [TIR]8), a negative regulator for Toll/IL-1R signaling, plays critical roles in innate immunity and various diseases in mammals. However, the occurrence of this molecule in ancient vertebrates and its function in liver homeostasis and disorders remain ...
Wei, Feng +5 more
openaire +2 more sources
Interleukin-37 suppresses tumor growth through inhibition of angiogenesis in non-small cell lung cancer [PDF]
, 2016 BACKGROUND: Interleukin-37 (IL-37), a newly identified member of the IL-1 family, has been known to play an immunosuppressive role in a variety of inflammatory disorders, but whether it participates in the regulation of pathogenesis of non-small cell ...
Aiqin Wang +6 more
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Profiling the Course of Resolving vs. Persistent Inflammation in Human Monocytes: The Role of IL-1 Family Molecules [PDF]
, 2020 Monocytes and macrophages have a central role in all phases of an inflammatory reaction. To understanding the regulation of monocyte activation during a physiological or pathological inflammation, we propose two in vitro models that recapitulate the ...
Boraschi, Diana +6 more
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Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction
Advanced Science, Volume 12, Issue 16, April 24, 2025.This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong +11 more
wiley +1 more source
Addictive Behaviors Reports, 2018 Introduction: The degree to which smokers quit successfully with varenicline is strongly associated with their adherence to the medication regimen. Thus, measuring varenicline adherence to identify smokers needing additional intervention is a priority ...
Grace Crawford +8 more
doaj +1 more source
The effect and mechanism of IL-1 R II / IL-1 RAcp in Autoimmune Myocarditis [PDF]
, 2016 【目的】白介素-1（IL-1）是一种T淋巴细胞激活因子，大量研究报道，在心肌炎急性期表达量明显升高。白介素1受体II型（IL-1RII）可以招募白介素1受体辅助蛋白（IL-1RAcp），从而拮抗IL-1β的作用。本课题目的为评估IL-1RII和IL-1RAcp的重组质粒对大鼠自身免疫性心肌炎（EAM）的作用，并进一步探讨其机制，为心肌炎的临床治疗提供理论基础。 【方法】首先在临床实验中，我们选取厦门市心血管病医院诊断明确的心肌炎住院患者28例，应用bio ...
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