Results 71 to 80 of about 1,127 (146)

Therapeutic Potential of IL‐37 in Cervical Cancer: Suppression of Tumour Progression and Enhancement of CD47‐Mediated Macrophage Phagocytosis

Molecular Carcinogenesis, Volume 64, Issue 3, Page 425-439, March 2025.
ABSTRACT As a promising therapeutic approach, immunotherapy is being extensively investigated in cervical cancer. Although immunotherapy has been validated to improve progression‐free survival and overall survival in clinical trials, the overall response rate for cervical cancer remains inadequate, necessitating further improvement. Interleukin (IL)‐37,
Yuan Feng, Lianlian Feng, Bingyu Wang, Teng Zhang, Baoxia Cui   +4 more
wiley   +1 more source

Progression in the In Vitro Macrophage Expansion

Journal of Immunology Research, Volume 2025, Issue 1, 2025.
Macrophages play essential roles in homeostasis and disease, and they were considered terminally differentiated cells that cannot proliferate. However, growing evidence shows that macrophages can self‐renew in homeostasis and multiple pathological states in vivo and artificial induction in vitro.
Yunpeng Wei, Jingzhao Yang, Wenhong Zu, Mengran Wang, Yong Zhao, Baohui Xu   +5 more
wiley   +1 more source

IL-37d enhances COP1-mediated C/EBPβ degradation to suppress spontaneous neutrophil migration and tumor progression

Cell Reports
Summary: The spontaneous migration of bone marrow neutrophils (BMNs) is typically induced by distant tumor cells during the early stage of the tumor and critically controls tumor progression and metastases.
Yaxin Guo, Yi Zhang, Yetong Guan, Nuo Chen, Ming Zhao, Yubin Li, Tian Zhou, Xinyue Zhang, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Lining Zhang, Yan Li   +13 more
doaj   +1 more source

Wandering pathways in the regulation of innate immunity and inflammation [PDF]

, 2017
AIRC, ERC grant, Ctr. No.
Mantovani, A
core   +1 more source

Modulation of intestinal IL-37 expression and its impact on the epithelial innate immune response and barrier integrity [PDF]

, 2023
Background and Aims: Intestinal epithelial cells separate the luminal flora from lamina propria immune cells and regulate innate immune responses in the gut.
Azabdaftari, Aline, Breiderhoff, Tilman, Bufler, Philip, Heuberger, Julian, Hudert, Christian, Kröhn, Laura, Zilbauer, Matthias   +6 more
core   +1 more source

French guidelines on TIPS: Indications and modalities

Liver International, Volume 44, Issue 9, Page 2125-2143, September 2024.
Abstract Transjugular intrahepatic portosystemic shunt (TIPS) has become essential in the treatment or prevention of portal hypertension‐related complications. In the early 1990s, the primary indication was refractory bleeding. It is now proposed for the treatment of ascites for the prevention of bleeding and in patients with vascular diseases of the ...
Hélène Larrue, Manon Allaire, Delphine Weil‐Verhoeven, Sandrine Barge, Dominique Thabut, Audrey Payance, Lucile Moga, Caroline Jézéquel, Florent Artru, Isabelle Archambeaud, Laure Elkrief, Frédéric Oberti, Charles Roux, Wim Laleman, Marika Rudler, Sébastien Dharancy, Nolwenn Laborde, Anne Minello, Thomas Mouillot, Elvire Desjonquères, Line Caroll Ntandja Wandji, Marc Bourlière, Nathalie Ganne‐Carrié, Christophe Bureau, for the Groupe collaboratif AFEF, Delphine Weil‐Verhoeven, Agnès Bonadona, Paul Calame, Cyrielle Després, Vincent Di Martino, Patrick Dukan, Manon Allaire, Antoine Monsel, Hélène Larrue, Sandrine Barge, Dominique Thabut, Jean‐Paul Cervoni, Charlotte Bouzbib, Aurélie Plessier, Audrey Payance, Andrea de Gottardi, Lucile Moga, Marie Irles, Anna Sessa, Caroline Jézéquel, Florent Artru, Arnaud Pauwels, Isabelle Archambeaud, Simon Ville, Clément Deltombe, Laure Elkrief, Louise Barbier, Frédéric Oberti, Carine Chagneau, Adrien Lannes, Christophe Aube, Antoine Bouvier, Charles Roux, Juan Carlos Garcia Pagan, Wim Laleman, Geert Maleux, Marika Rudler, Nicolas Weiss, Sébastien Dharancy, Audrey Coilly, François Faitot, Anne Minello, Marie‐Astrid Piquet, Marianne Latournerie, Romaric Loffroy, Thomas Mouillot, Eric Assenat, Nathalie Ganne‐Carrié, Boris Guiu   +73 more
wiley   +1 more source

Stimuli‐Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms–Macrophage Interface

Advanced Healthcare Materials, Volume 13, Issue 20, August 7, 2024.
A schematic depiction of the effects of various physical stimulations on the polarization of macrophage cells is presented. These effects dramatically alter when stimulation is applied in conjugation with micro/nanoplatforms. The synergistic role of micro/nanoplatforms and physical stimuli can be utilized to fabricate innovative immunomodulatory ...
Keya Ganguly, Rachmi Luthfikasari, Aayushi Randhawa, Sayan Deb Dutta, Tejal V. Patil, Rumi Acharya, Ki‐Taek Lim   +6 more
wiley   +1 more source

Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein

Chemistry – A European Journal, Volume 30, Issue 23, April 22, 2024.
47 derivatives of a potent α‐synuclein aggregate binding pyridothiophene (asyn‐44) were synthesized and screened against [3H]asyn‐44 in competitive binding assays using post‐mortem Parkinsons disease brain homogenates and Ki values of the most potent compounds were determined.
Anna Pees, Junchao Tong, Saritha Birudaraju, Yogeshkumar S. Munot, Steven H. Liang, Dinahlee Saturnino Guarino, Robert H. Mach, Chester A. Mathis, Neil Vasdev   +8 more
wiley   +1 more source

The Role of IL-1R8 in Modulating Macrophage Inflammation: Implications for Atherosclerosis. [PDF]

, 2017
M.S. Thesis.
Liu, Chloe Anne O. Y.
core  

Emerging Roles of Macrophage Polarization in Osteoarthritis: Mechanisms and Therapeutic Strategies

Orthopaedic Surgery, Volume 16, Issue 3, Page 532-550, March 2024.
Macrophages are key players in osteoarthritis (OA) pathology. In this review, we focus on synovial macrophages, adipose tissue macrophages, and osteoclasts, to investigate their roles in the development of OA. We review recent key findings related to macrophage polarization and OA, including pathogenesis, molecular pathways, and novel therapeutics ...
Zimu Yuan, Decheng Jiang, Mengzhu Yang, Jie Tao, Xin Hu, Xiao Yang, Yi Zeng   +6 more
wiley   +1 more source