Results 81 to 90 of about 1,127 (146)

IL-1 and IL-1 regulatory pathways in cancer progression and therapy [PDF]

, 2018
The financial support of Fondazione Cariplo (Contract no. 2015-0564), Ministero della Salute (RF-2011-02348358 and RF-2013-02355470), Ministry of Education, University and Research (PRIN 2015YYKPNN), the European Research Council (ERC – No.
Apte, Bhat, Biswas, Bronte, Carmi, Cataisson, Chirivi, Colotta, Coussens, Dinarello, Dinarello, El-Omar, Elkabets, Elkabets, Galdiero, Garlanda, Garlanda, Giavazzi, Hong, Hu, Krelin, Li, Lind, Lust, Mantovani, Mantovani, Mantovani, Mantovani, Mantovani, McKenzie, Molgora, Molgora, Murphy, Netea, Nold-Petry, Noy, Pan, Ridker, Ridker, Roy, Salcedo, Tannahill, Thomas, Vidal-Vanaclocha, Vidal-Vanaclocha, Vidal-Vanaclocha, Voronov, Voronov, Wang, Xiao, Zienolddiny   +50 more
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IL-37 protects against house dust mite-induced airway inflammation and airway epithelial barrier dysfunction via inhibiting store-operated calcium entry [PDF]

Background: Airway epithelial barrier dysfunction has been proved to contribute to the development of type 2 inflammation of asthma. Interleukin (IL)-37 is a negative regulator of immune responses and allergic airway inflammation.
Akdiş, Cezmi A, Cao, Can, Fu, Wei, Gao, Yadong, Hu, Jiaqian, Ma, Ruxue, Qi, Shiquan, Wang, Changchang, Zhang, Xiaolian, Zhong, Jian   +9 more
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IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential. [PDF]

, 2019
The interleukin (IL)-1 family of cytokines is composed of 11 members, including the most recently discovered IL-36α, β, γ, IL-37, and IL-38. Similar to IL-1, IL-36 cytokines are initiators and amplifiers of inflammation, whereas both IL-37 and IL-38 ...
Alessandra Nerviani, Batliwalla, Costantino Pitzalis, Debets, Goldring, Marie-Astrid Boutet   +5 more
core   +1 more source

IL-1R8 Acts As An Immune Checkpoint In CD8⁺ T Cells

, 2020
IL-1R8 is a member of the Interleukin-1 receptor (ILR) family, acting as a negative regulatory receptor that inhibits inflammation by dampening ILR and Toll-like receptor (TLR) signaling pathways. IL-1R8 deficiency was shown to enhance IL-18-promoted NK cell effector functions restraining tumor metastasis and viral dissemination.
openaire   +1 more source

The yin-yang of the interaction between myelomonocytic cells and NK cells [PDF]

, 2018
NK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular,
Agaugue, Andrews, Anfossi, Aranha, Atochina, Baratin, Barrow, Basu, Bellora, Bellora, Bellora, Benigni, Bhatnagar, Biswas, Bordignon, Brill, Brodin, Costantini, Costantini, Costantini, Denis, el-Hag, Elhaik-Goldman, Emoto, Fauriat, Fehniger, Fernandez, Gabrilovich, Gaggero, Garlanda, Gerosa, Granucci, Gregoire, Haller, Harlin, Hart, Hartl, Herberman, Hoglund, Huntington, Jaeger, Kadri, Karre, Karre, Kassim, Kiessling, Kiessling, Kim, Klezovich-Benard, Koka, Kumar, Landazuri, Lanier, Laouar, Lapaque, Lauzon, Lavin, Liao, Lindemann, Locati, Long, Lucas, Lunemann, Ma, Malmberg, Mantovani, Marcenaro, Martin-Fontecha, Mattiola, Mavilio, Michel, Mingozzi, Molgora, Molgora, Moretta, Moretta, Moretta, Nakajima, Nedvetzki, Nguyen, Ogura, Parham, Pesce, Raulet, Raulet, Riise, Robertson, Romo, Seaman, Shau, Shau, Shau, Shi, Sica, Sivori, Smith, Stabile, Tasca, Thoren, Tripp, Vari, Vivier, Vivier, Vivier, Vogel, Vulpis, Walzer, Wetering, Yokoyama, Zanoni, Zimmer   +110 more
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Agree to disagree: The contradiction between IL-18 and IL-37 reveals shared targets in cancer

Pharmacological Research
IL-37 is a newly discovered member of the IL-1 cytokine family which plays an important role in regulating inflammation and maintaining physiological homeostasis.
Dongjie Wang, Bitian Zhang, Xiaolin Liu, Lea Ling-Yu Kan, Ping-Chung Leung, Chun-Kwok Wong   +5 more
doaj   +1 more source

Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis [PDF]

, 2019
Inflammatory bowel disease increases the risk of developing colon cancer. Interleukin (IL-) 37 is a fundamental inhibitor of innate immunity by reducing systemic and local inflammation.
Bufler, Philip, Dinarello, Charles A., Kobold, Sebastian, Mayr, Doris, Mountford, Steffeni, Ringleb, Andrea, Schwaiger, Rahel   +6 more
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Der Einfluss der GDF15-bedingten Modulation von IL-37 auf Parodontalligament-Fibroblasten während der mechanischen Zugbelastung [PDF]

Während der kieferorthopädischen Zahnbewegung (OTM) werden im parodontalen Ligament (PdL) Bereiche mit Druck- und Zugkräften erzeugt. Mechanisch stimulierte PdL-Fibroblasten (PdLFs), der Hauptzelltyp des PdL, exprimieren signifikant erhöhte Mengen des ...
Viehöfer, Julia
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Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils [PDF]

, 2018
IL-1 family regulatory cytokine IL-37b can suppress innate immunity and inflammatory activity in inflammatory diseases. In this study, IL-37b showed remarkable in vitro suppression of inflammatory tumor necrosis factor-α, IL-1β, IL-6, CCL2, and CXCL8 ...
Christopher Wai-Kei Lam, Chun-Kwok Wong, Chun-Kwok Wong, Chun-Kwok Wong, Dehua Liu, Dehua Liu, Delong Jiao, Jie Dong, Jing Zhu, Lai Guan Ng, Lu Ji, Miranda Sin-Man Tsang, Miranda Sin-Man Tsang, Peiyong Jiang, Ting Fan Leung   +14 more
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