Results 191 to 200 of about 125,946 (236)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Health professionals' knowledge and understanding of inclusion health: a systematic literature review. [PDF]

Health Policy Plan
Flynn AV, Bermingham M, Caples M, Curtin M, Dalton C, McLoughlin G, O'Mahony J, Vucen S, Saab MM.   +8 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

"Street sweeps": The municipal government-enforced confiscation of personal belongings among unstably housed people who use drugs in Vancouver, Canada. [PDF]

Public Health
Eren IM, Sayre EC, Shane C, P.O.W.E.R, Singh Kelsall T, Beatrice M, Sudds R, DeBeck K, Milloy MJ, Kerr T, Hayashi K.   +10 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

From housing to home and belonging: structural violence, ontological (in)security and women's mental health. [PDF]

Front Sociol
Keynejad RC, Gaifém F, Nikolić I, Belay S, Amare HH, Abera H, Mautner MC, Lichtwarck HO, Eick F.   +8 more
europepmc   +1 more source

Conformal Reconfigurable Intelligent Surfaces: A Cylindrical Geometry Perspective

Advanced Electronic Materials, EarlyView.
Cylindrical reconfigurable intelligent surfaces are explored for low‐complexity beam steering using one‐bit meta‐atoms. A multi‐level modeling approach, including optimization‐based synthesis, demonstrates that even minimal hardware can support directive scattering.
Filippo Pepe, Ivan Iudice, Giuseppe Castaldi, Marco Di Renzo, Vincenzo Galdi   +4 more
wiley   +1 more source

Re-storying health promotion models toward population sovereignty. [PDF]

Front Public Health
Olson K, Erb M, Si'al E, Piechowski A, Riegert J, Ranjbar N.   +5 more
europepmc   +1 more source

Competition Policy and Agribusiness in the Biden Administration

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The Biden Administration pursued a set of ambitious competition policy initiatives in agriculture and agribusiness, primarily aimed at livestock and poultry supply chains, farm inputs, and food retailing. The initiatives included expanded antitrust enforcement; new US Department of Agriculture (USDA) contract regulations requiring poultry ...
James M. MacDonald
wiley   +1 more source

Maternal and Infant Outcomes for Women Experiencing Homelessness Before and During Pregnancy: A Retrospective Cohort Study. [PDF]

BJOG
Geddes-Barton D, Goldacre R, Luchenski S, Daniels C, D Arcy R, Knight M, Vousden N.   +6 more
europepmc   +1 more source