Results 31 to 40 of about 988,939 (305)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Regularization and Error Estimate for the Poisson Equation with Discrete Data

open access: yesMathematics, 2019
In this work, we focus on the Cauchy problem for the Poisson equation in the two dimensional domain, where the initial data is disturbed by random noise.
Nguyen Anh Triet   +3 more
doaj   +1 more source

Comparing parameter choice methods for regularization of ill-posed problems [PDF]

open access: yes, 2011
In the literature on regularization, many different parameter choice methods have been proposed in both deterministic and stochastic settings. However, based on the available information, it is not always easy to know how well a particular method will ...
Bauer, F., Lukas, M.A.
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Is the universe ill-posed?

open access: yes, 2020
We discuss an unusual consequence of the behaviour of general relativistic cosmological models when they initial value problem is not well-posed because of the lack of the local Lipschitz condition. A new type of 'zero universe' arises with vanishing scale factor, and its first time derivative, at all times.
openaire   +2 more sources

Describing the phenomena of students’ representation in solving ill-posed and well-posed problems [PDF]

open access: yes, 2018
Mathematical representation is an essential aspect of mathematical problem-solving. But students’ ability of an accurate representation in ill-posed problem-solving is still very minimal compared to that in well-posed problem-solving.
Santia, Ika, Rofiki, Imam
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Retrieval of kinetic rates in reactions with semi batch liquid phase using ill-posed inverse problem theory

open access: yesQuímica Nova, 2011
A neural network procedure to solve inverse chemical kinetic problems is discussed in this work. Rate constants are calculated from the product concentration of an irreversible consecutive reaction: the hydrogenation of Citral molecule, a process with ...
Rita C. O. Sebastião   +3 more
doaj   +1 more source

Complexity of Linear Ill-Posed Problems in Hilbert Space

open access: yes, 2017
Information complexity of ill-posed problems may be seen as controversial. On the one hand side there were pessimistic results stating that the complexity is infinite, while on the other hand side the theory of ill-posed problems is well developed.
Mathé, Peter, Pereverzev, Sergei V.
core   +1 more source

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