Results 91 to 100 of about 76,152 (305)

A Generalized Tikhonov Regularization Using Two Parameters Applied to Linear Inverse Ill-Posed Problems

open access: yesRevista de Ciencias, 2007
A Generalized Tikhonov Regularization Using Two Parameters Applied to Linear Inverse Ill-Posed ...
Doris Hinestroza, Luisa Fernanda Vargas
doaj   +1 more source

The method of fundamental solutions for Helmholtz-type problems [PDF]

open access: yes, 2013
The purpose of this thesis is to extend the range of application of the method fundamental solutions (MFS) to solve direct and inverse geometric problems associated with two- or three-dimensional Helmholtz-type equations.
Bin-Mohsin, Bandar Abdullah
core  

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

open access: yesAdvanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu   +8 more
wiley   +1 more source

Physics‐Informed Estimation of Tidal and Subtidal Flow Fields From ADCP Repeat Transect Data

open access: yesWater Resources Research
Acoustic Doppler current profilers (ADCPs) are a global standard in observing flow fields in rivers, estuaries and the coastal ocean. To date, it remains a labor intensive challenge to isolate mean flow fields governed by river discharge, tides and ...
H. Jongbloed   +2 more
doaj   +1 more source

A simplified homotopy perturbation method for solving nonlinear ill-posed operator equations in Hilbert spaces

open access: yesJournal of Numerical Analysis and Approximation Theory
One popular regularization technique for handling both linear and nonlinear ill-posed problems is homotopy perturbation. In order to solve nonlinear ill-posed problems, we investigate an iteratively-regularized simplified version of the Homotopy ...
Sharad Kumar Dixit
doaj   +1 more source

Engineering an Optogenetic pH‐Modulator in Bacteria

open access: yesAdvanced Science, EarlyView.
ABSTRACT Cells in many naturally occurring organisms routinely cooperate to control their extracellular pH in a dynamic and reversible manner, but this capability has been underexplored in synthetic biology. Here, we sought to engineer a microbial system that switches between two states —high and low extracellular pH— with minimal human intervention ...
Jenevieve Kuang   +7 more
wiley   +1 more source

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

open access: yesAdvanced Science, EarlyView.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

open access: yesAdvanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang   +8 more
wiley   +1 more source

On the ill-posed problem for the Poisson equation

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2018
A boundary value problem in a two - dimensional rectangular region for the Poisson equation is studied in the paper. The original ill - posed boundary value problem is transformed to the optimal control problem.
M.T. Jenaliyev   +2 more
doaj   +1 more source

A quasi-boundary-value method for the Cauchy problem for elliptic equations with nonhomogeneous Neumann data

open access: yes, 2010
A Cauchy problem for elliptic equations with nonhomogeneous Neumann datain a cylindrical domain is investigated in this paper. For the theoretical aspect the a-prioriand a-posteriori parameter choice rules are suggested and the corresponding error ...
Xiao-Li Feng   +5 more
core   +1 more source

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