Results 111 to 120 of about 76,152 (305)
Advanced Science, EarlyView.We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du +11 more
wiley +1 more source
An Optimally Generalized Steepest-Descent Algorithm for Solving Ill-Posed Linear Systems
Journal of Applied Mathematics, 2013 It is known that the steepest-descent method converges normally at the first few iterations, and then it slows down. We modify the original steplength and descent direction by an optimization argument with the new steplength as being a merit function to ...
Chein-Shan Liu
doaj +1 more source
Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design
Advanced Science, EarlyView.Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng +7 more
wiley +1 more source
Convergence rates of general regularization methods for statistical inverse problems and applications [PDF]
During the past the convergence analysis for linear statistical inverse problems has mainly focused on spectral cut-off and Tikhonov type estimators. Spectral cut-off estimators achieve minimax rates for a broad range of smoothness classes and operators,
Bissantz, Nicolai +3 more
core
Advanced Science, EarlyView.Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes +15 more
wiley +1 more source
A bootstrap multi-user detector for CDMA based on Tikhonov regularization
, 2003 A novel multi-user detection (MUD) technique for CDMA systems is introduced. The new method is well suited for cases in which the code cross correlation matrix is ill-conditioned.
Nix, AR +3 more
core
Why a minimizer of the Tikhonov functional is closer to the exact solution than the first guess
, 2011 Suppose that a uniqueness theorem is valid for an ill-posed problem. It is shown then that the distance between the exact solution and terms of a minimizing sequence of the Tikhonov functional is less than the distance between the exact solution and the ...
Klibanov, M. V. +8 more
core +1 more source
Conformal Reconfigurable Intelligent Surfaces: A Cylindrical Geometry Perspective
Advanced Electronic Materials, EarlyView.Cylindrical reconfigurable intelligent surfaces are explored for low‐complexity beam steering using one‐bit meta‐atoms. A multi‐level modeling approach, including optimization‐based synthesis, demonstrates that even minimal hardware can support directive scattering.
Filippo Pepe +4 more
wiley +1 more source
Doppler Positioning with LEO Mega-Constellation: Equation Properties and Improved Algorithm
Remote SensingDoppler positioning, as an early form of positioning, has regained significant research interest in the context of Low Earth Orbit (LEO) satellites.Given the LEO mega-constellation scenario, the objective function of Doppler positioning manifests ...
Zichen Xu +6 more
doaj +1 more source
Inverse problems in demography and biodemography [PDF]
Inverse problems play important role in science and engineering. Estimation of boundary conditions on the temperature distribution inside a metallurgical furnace, reconstruction of tissue density inside body on plane projections obtained with x-rays are ...
Anatoli I. Michalski
core