Results 81 to 90 of about 7,949,694 (307)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
National Treatment Purchase Fund annual report 2004.
, 2004 The mission of the National Treatment Purchase Fund is to reduce the length of time public patients are on hospital waiting lists by offering them a choice in obtaining access to treatment quickly, safely and to a high standard of patient satisfaction ...
National Treatment Purchase Fund
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Nurses’ Knowledge and Practices Related to Pain Assessment in Critically ill Patients at Mulago Hospital, Uganda [PDF]
, 2012 Nurses’ knowledge and practices related to pain assessment in critically ill patients at Mulago National Hospital, Uganda. Critically ill patients experience moderate to severe acute pain which minimizes their comfort. If inadequately managed, acute pain
Kizza, I.B, Kizza, Irene Betty
core
Health Psychology Open, 2018 This study examines the importance of four psychosocial factors—personality, cognitive appraisal of quality of life, social support, and current reserve-building—in predicting treatment burden in chronically ill patients.
Carolyn E Schwartz +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
National Treatment Purchase Fund annual report 2004
, 2005 2004 has been a busy and successful year for the National Treatment Purchase Fund (NTPF)The NTPF is one of the initiatives outlined in the Health Strategy and Programme for Government and was set up in April 2002.
National Treatment Purchase Fund
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
BioResources, 2022 Ionic liquids (ILs) have been widely used for lignocellulose fractionation and lignin isolation. However, the effect of IL treatment on lignin structure has been less explored.
Eun-Ah Lee +11 more
doaj +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source