Results 101 to 110 of about 72,615 (261)
A dedicated caller for DUX4 rearrangements from whole-genome sequencing data
BMC Medical GenomicsRearrangements involving the DUX4 gene (DUX4-r) define a subtype of paediatric and adult acute lymphoblastic leukaemia (ALL) with a favourable outcome. Currently, there is no ‘standard of care’ diagnostic method for their confident identification.
Pascal Grobecker +15 more
doaj +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2019 The complete mitochondrial genome of a cryptic species of tadpole shrimp from South Africa (Accession Number: MG770893) was recovered by low coverage shotgun sequencing. The mitogenome consists of 15,216 bp with a GC content of 30.95%.
Han Ming Gan +3 more
doaj +1 more source
Illumina CanineHD Beadchip data
, 2015 Illumina CanineHD Beadchip data of whippets - traditional ped based format for ...
Hsue, Weihow +11 more
core +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2019 Herein, we first determined the complete mitochondrial genome of Turricula nelliae spurius in this study. The circular mitochondrial genome is 16,450 bp in length, consisting of 13 protein-coding genes, 22 tRNA genes, and two ribosomal RNA genes.
Zeqin Fu +6 more
doaj +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2017 The Devil Ray (Mobula thurstoni) is a species with global distribution and is an important species in conservation terms, here we present its complete mitochondrial genome assembled with Illumina sequencing data.
Betsaida Santillán-Lugo +5 more
doaj +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
Scalable screening of ternary-code DNA methylation dynamics associated with human traits
Cell GenomicsSummary: Epigenome-wide association studies (EWASs) are transforming our understanding of the interplay between epigenetics and complex human traits.
David C. Goldberg +19 more
doaj +1 more source