Results 91 to 100 of about 531,444 (314)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

P565: Optimized whole genome screening: The impact of variant calling accuracy improvements on curation burden

Genetics in Medicine Open, 2023
Kristen Sund, Samuel Strom, Pauline Fujita, Batsal Devkota, Jennifer Shah, Nathan Berkowitz, LeAnne Lovato, Elliott Margulies, Mitch Bekritsky   +8 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

P507: Implementation of automated pharmacogenomics reporting for a clinically validated whole genome sequencing test

Genetics in Medicine Open, 2023
Alka Malhotra, Rueben Hejja, James Avecilla, Andrew Walker, Phillip Medrano, Felipe Mullen, Anusha Balusu, Pratyusha Vankayala, Maren Bennett, Aditi Chawla, Subramanian Ajay, Samuel Strom, Akanchha Kesari, Denise Perry, Ryan Taft   +14 more
doaj   +1 more source

Illumina complete long read assay yields contiguous bacterial genomes from human gut metagenomes

mSystems
Metagenomics enables direct investigation of the gene content and potential functions of gut bacteria without isolation and culture. However, metagenome-assembled genomes are often incomplete and have low contiguity due to challenges in assembling ...
Dylan G. Maghini, Yuya Kiguchi, Aaron E. Darling, Leigh G. Monahan, Aaron L. Halpern, Catherine M. Burke, Erich Jaeger, Aaron Statham, Tiffany Truong, Kevin Ying, Stephen P. Bruinsma, Gary P. Schroth, Ami S. Bhatt   +12 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Hybrid Enterobacteriaceae assemblies using PacBio+Illumina or ONT+Illumina sequencing

, 2019
Data associated with: De Maio, Shaw, et al. on behalf of the REHAB consortium (2019), Comparison of long-read sequencing technologies in the hybrid assembly of complex bacterial genomes. biorxiv 530824 Illumina sequencing allows rapid, cheap and accurate
Nicola De Maio (233448), Liam Shaw (5487083), The REHAB Consortium (6276655)   +2 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Raw Illumina files

, 2018
Raw Illumina ...
Thainara Souza (3917138), Alexandre Aleixo (2929941), Weber Silva (3917147), Gregory Thom (5392181), Fábio Raposo do Amaral (797056), Péricles Rêgo (3917144), Marcos Coelho (5392184), Leilton Luna (3917141), Juliana Araripe (287322)   +8 more
core   +1 more source

P420: Development of a comprehensive cardiovascular disease whole genome sequencing test

Genetics in Medicine Open, 2023
Laura Amendola, Alison Coffey, Samuel Strom, Akanchha Kesari, James Avecilla, Josh Lowry, Stetson Thacker, Julie Taylor, Kathryn Golden-Grant, Matt Brown, Becky Milewski, John Belmont, Denise Perry, Ryan Taft   +13 more
doaj   +1 more source