Results 91 to 100 of about 835,839 (289)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Illustration: A Concise History [PDF]
An indispensable guide to the international history of illustrated images, from 1750 to the present day. Illustration: A Concise History is a dynamic visual journey through the landscape of illustration that maps the evolution of the discipline from ...
Hall, Andrew
core +3 more sources
Architecture and Visual Narrative
Architecture communication tools have been implemented in recent history by strategies and narrative artifices imported from cinema, comic, photo-journalism and infographic. The architect has integrated the traditional encoded drawing with more extensive
Fabio Quici
doaj +1 more source
Book synopsis: William Blake, poet and artist, is a figure often understood to have 'created his own system'. Combining close readings and detailed analysis of a range of Blake's work, from lyrical songs to later myth, from writing to visual art, this collection of thirty-eight lively and authoritative essays examines what Blake had in common with his ...
openaire +1 more source
Illustration - Drawing of Pig while Blindfolded, Dorothy Wetherald
The illustration of a pig is part of an autograph book collection of Ethelwyn Wetherald. Her guest book consists of drawings of pigs her guests create while blindfolded. The signature of each guest accompanies the illustration.
core
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Illustration as an announcement of a world [PDF]
Illustration is often casually assumed to be a representational practice, where ‘something out there’ is represented, i.e. shown again, in visual form. The prefix ‘re-’ in ‘representation’ suggests that something exists prior to its pictorial rendering ...
Vormittag, Luise
core +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source

