Molecular determinants of signal transduction in tropomyosin receptor kinases
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
New observation on <i>Corynetis</i> from the early Cambrian Guanshan Biota reflect burrowing life. [PDF]
Liu C, Liu J.
europepmc +1 more source
Jochen Lingelbach. On the Edge of Whiteness: Polish Refugees in British Colonial Africa during and after the Second World War. Oxford: Berghahn Books, 2023. xi + 306 pp. 15 Illustrations. Bibliography. Index. $27.95. Paper. ISBN: 978-1-78920-444-5. [PDF]
Marta Cieślak
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Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
Correction: The Gulliver syndrome: a conceptual framework to address therapeutic inertia in patients with borderline cardiovascular risk profiles. [PDF]
López-Gil JF +2 more
europepmc +1 more source
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
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Lateral transorbital neuroendoscopic approach using the superior eyelid incision: A straightforward, comprehensive, and illustrative step-by-step review. [PDF]
Chavez-Herrera VR +12 more
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Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source

