Results 121 to 130 of about 390,298 (260)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Caulinia bimaculata O. Kuntze [picture] /
, 1900 Inscriptions: title below image, "F.P. Nodder pinxit 1777." -- lower left.; Plate 68 of Illustrations of the botany of Captain Cook's voyage round the world in H.M.S.
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Cricket and the Ant: Fable by Jean de la Fontaine
, 1955 Here is the English version of a booklet I already have in French from the same publisher and artist and similarly listed under 1955? There Tante Tsylla et Frédérique Laurant were acknowledged as the writers of the explanatory story; here Ann Lewis and ...
La Fontaine, Jean de +2 more
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, 2017 Botanical illustrations were an integral facet of botany in the Renaissance era. Many naturalists and physicians studied plants in collections to observe and record the naturalia.
Roush, Emily N.
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ARQ, 2010 El paisaje es intervenido para volver a lo natural, con el objetivo de ser utilizado por los reyes en las temporadas de caza. Forzadamente se introducen especies de flora y fauna en un lugar para configurar jardines que hoy reconocemos como parques.
Romy Hecht
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 1973 Here is a twelve-page large-format pamphlet portraying part of Mes Fables d'Animaux from Touret, for which edition I have guessed a date of 1975. This pamphlet measures 9 x 11¾.
Aesop, Giros, Patricia
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Illustrations en couleurs / Colour illustrations
, 2011 Illustrations en couleurs / Colour illustrations. In: Le tell d'Akkaz au Koweït / Tell Akkaz in Kuwait Lyon : Maison de l'Orient et de la Méditerranée Jean Pouilloux, 2011. pp. 1-4.
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