Results 51 to 60 of about 21,126 (243)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

MagicTalk: Implicit and explicit correlation learning for diffusion-based emotional talking face generation

Computational Visual Media
Generating emotional talking faces from a single portrait image remains a significant challenge. The simultaneous achievement of expressive emotional talking and accurate lip-sync is particularly difficult, as expressiveness is often compromised for lip ...
Chenxu Zhang, Chao Wang, Jianfeng Zhang, Hongyi Xu, Guoxian Song, You Xie, Linjie Luo, Yapeng Tian, Jiashi Feng, Xiaohu Guo   +9 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Rapid Path Planning Algorithm for Percutaneous Rigid Needle Biopsy Based on Optical Illumination Principles

Sensors
Optimal needle trajectory selection is critical in biopsy procedures to minimize tissue damage and ensure diagnostic accuracy. Timely trajectory planning is essential, as it relies on preoperative CT imaging.
Jian Liu, Shuai Kang, Juan Ren, Dongxia Zhang, Bing Niu, Kai Xu   +5 more
doaj   +1 more source

Global Structure-From-Motion Enhanced Neural Radiance Fields 3D Reconstruction [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Urban three-dimensional modeling involves digitizing geographical elements such as urban ground and architecture, profoundly impacting urban management, planning, and development.
T. Ye, H. Huang, Y. Liu, J. Yang
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Overview of 3D Scene Viewpoints evaluation method

Virtual Reality & Intelligent Hardware, 2019
The research on 3D scene viewpoints has been a frontier problem in computer graphics and virtual reality technology. In a pioneering study, it had been extensively used in virtual scene understanding, image-based modeling, and visualization computing ...
Yan Zhang, Guangzheng Fei
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

MedNeXt for accurate medical image classification and segmentation: A lightweight transformer-style convolutional neural network.

PLoS ONE
Transformer-based deep learning architectures have achieved notable success across various medical image analysis tasks, driven by the global modeling capabilities of the self-attention mechanism.
Ziqing Xue, Pengpeng Pi, Ziyi Liu, Zhaomu Zeng, Zhiwei Sun   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source