Results 71 to 80 of about 12,109,327 (298)

Clinical and radiographic response of a paravertebral hemangioma to radiotherapy

Radiology Case Reports
Hemangiomas can arise anywhere in the body. While vertebral hemangiomas are common, atypical hemangiomas with paraspinal and epidural extension are rare. We present a case of a patient who presented with persistent cough and anorexia from a paravertebral
Laura Burgess, MSc, MD, Julia Malone, BSc, Marlise P. dos Santos, MSc,MPH, MD, John Sinclair, MD, Osbert Zalay, MD, PhD, Shawn Malone, MD   +5 more
doaj   +1 more source

Molecular image-guided radiotherapy with positron emission tomography

, 2009
Molecular image-guided radiotherapy with positron emission ...
Grégoire, Vincent, Haustermans, Karin, Karin Haustermans, John Lee, Vincent Grégoire, Lee, John Aldo   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Image-guided radiotherapy in upper gastrointestinal malignancies: an Italian survey by the AIRO gastrointestinal study group

Oncologie
Image-guided radiation therapy (IGRT) plays a central role in modern radiotherapy. However, due to a lack of standardised guidelines for image acquisition, timing, and motion management protocols, considerable variation exists in clinical practice.
de Franco Paola, Galofaro Elena, De Renzi Filippo, De Felice Francesca, Famà Lia, Valenti Marco, Iosca Nicola, Pisoni Valerio, Votta Claudio, Cellini Francesco, Alaimo Rita, Montesi Giampaolo, Simoni Nicola, Lupattelli Marco, Mantello Giovanna, Niespolo Rita M.   +15 more
doaj   +1 more source

Whole Brain Radiotherapy Combined with Simultaneous Integrated Boost for Brain Metastases of Lung Cancer: Its Clinical Effectiveness and Prognosis

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the shorter-term curative efficacy and safety of whole brain radio therapy(WBRT) combined with simultaneous integrated boost versus sequential integrated boost using image-guided intensity-modulated radiotherapy (IG-IMRT) for ...
HE Jun, ZHANG Chengda, JIA Lin, HAN Jianjun, GAO Fei, WANG Yun, JIA Li, JIA Dong, CHEN Yan   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Image-Guided Orthopaedic Surgery [PDF]

, 2013
Image-guided surgery systems are increasingly being used during orthopaedic interventions. The aim of this chapter is to present the basic elements of these image-guided orthopaedic surgery (IGOS) devices and to review examples of preoperative or intra ...
Nolte, Lutz-Peter, Zheng, Guoyan, Lutz-P. Nolte, Guoyan Zheng   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Prostate Radiotherapy in the Era of Advanced Imaging and Precision Medicine

Prostate Cancer, 2016
Tremendous technological advancements in prostate radiotherapy have decreased treatment toxicity and improved clinical outcomes for men with prostate cancer.
Caleb R. Dulaney, Daniel O. Osula, Eddy S. Yang, Soroush Rais-Bahrami   +3 more
doaj   +1 more source