Results 231 to 240 of about 13,444,099 (340)

Fabrication of a hyaluronic acid conjugated metal organic framework for targeted drug delivery and magnetic resonance imaging

, 2018
Fangpeng Shu, Daojun Lv, Xian‐Lu Song, Bin Huang, Chong Wang, Yu‐Zhong Yu, Shan‐Chao Zhao   +6 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A bi-channel aided stitching of atomic force microscopy images. [PDF]

Sci Rep
Zhao H, Millan-Solsona R, Checa M, Brown SR, Morrell-Falvey JL, Collins L, Biswas A.   +6 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Synthesis and perceptual scaling of high-resolution naturalistic images using Stable Diffusion. [PDF]

Behav Res Methods
Pettini L, Bogler C, Doeller C, Haynes JD.   +3 more
europepmc   +1 more source

Prefrontal activity in Huntington's disease reflects cognitive and neuropsychiatric disturbances: The IMAGE-HD study

, 2012
Marcus A. Gray, Gary F. Egan, Ayaka Ando, Andrew Churchyard, Phyllis Chua, Julie C. Stout, Nellie Georgiou‐Karistianis   +6 more
openalex   +2 more sources

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

HyperSight CBCT image quality and metal artifact reduction for adaptive head and neck radiotherapy: Results from a prospective clinical trial. [PDF]

J Appl Clin Med Phys
Yashayaeva A, MacDonald RL, Zhan K, DeGiobbi J, McMaster N, McAloney D, Ward L, Anderson C, LeBlanc M, Best L, Rajaraman M, Wilke D, Cherpak A.   +12 more
europepmc   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Rolling shutter-resistant confocal endomicroscopy image stitching via dual-path Gaussian U-Net. [PDF]

J Biomed Opt
Lu Y, Chen S, Liu Q.
europepmc   +1 more source