Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Language-guided Medical Image Segmentation with Target-informed Multi-level Contrastive Alignments [PDF]
arXivMedical image segmentation is crucial in modern medical image analysis, which can aid into diagnosis of various disease conditions. Recently, language-guided segmentation methods have shown promising results in automating image segmentation where text reports are incorporated as guidance.
arxiv
Ion imaging measurement of collision-induced rotational alignment in Ar-NO scattering [PDF]
, 2001 Joseph I. Cline +4 more
openalex +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
End-to-end robust joint unsupervised image alignment and clustering. [PDF]
Proc IEEE Int Conf Comput Vis, 2021 Zeng X, Howe G, Xu M.
europepmc +1 more source
Generalizing Alignment Paradigm of Text-to-Image Generation with Preferences through $f$-divergence Minimization [PDF]
arXivDirect Preference Optimization (DPO) has recently expanded its successful application from aligning large language models (LLMs) to aligning text-to-image models with human preferences, which has generated considerable interest within the community. However, we have observed that these approaches rely solely on minimizing the reverse Kullback-Leibler ...
arxiv
Subresolution placement using infrared image alignment to the computer-aided design database for backside probing and editing [PDF]
, 2001 M. Sengupta +3 more
openalex +1 more source
Image Correlation Method for DNA Sequence Alignment
PLoS ONE, 2012 The complexity of searches and the volume of genomic data make sequence alignment one of bioinformatics most active research areas. New alignment approaches have incorporated digital signal processing techniques. Among these, correlation methods are highly sensitive.
Iván Maureira Butler +4 more
openaire +4 more sources
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Medical image alignment based on landmark- and approximate contour-matching. [PDF]
J Med Imaging (Bellingham), 2021 Mojica M, Pop M, Ebrahimi M.
europepmc +1 more source