Results 131 to 140 of about 6,105,660 (335)

Topographic and quantitative correlation of structure and function using deep learning in subclinical biomarkers of intermediate age-related macular degeneration

Scientific Reports
To examine the morphological impact of deep learning (DL)-quantified biomarkers on point-wise sensitivity (PWS) using microperimetry (MP) and optical coherence tomography (OCT) in intermediate AMD (iAMD).
Klaudia Birner, Gregor S. Reiter, Irene Steiner, Gábor Deák, Hamza Mohamed, Simon Schürer-Waldheim, Markus Gumpinger, Hrvoje Bogunović, Ursula Schmidt-Erfurth   +8 more
doaj   +1 more source

Image and Diagnosis Analysis of Multi-Slice Spiral CT and Chest X-Ray of Neonatal Pneumonia [PDF]

, 2022
Liulin Wang, H Mahnken, J Wildberger, A M Sinha, M Rahmati, M Ahmadi, Malekmohamadi, B Joob, V Wiwanitkit, Gentile, J Bakir, L Bialorus, Z Q Lin, X Q Xu, K B Zhang, Liao Caihong, Li Qingxue, Hu Xianhua, Lin Xizhou, Chen Hongxia, Duan Minjun, Feng Hongbin, S M Lee, Y Cho, Y M Sung, C Macdonald, S Jayathissa, M Leadbetter, T Rahman, M E H Chowdhury, A Khandakar, R Ruslie, D Tjipta, C Samosir, A Mittal, D Kumar, M Mittal, S Anuradha, S Ghosh, R Dewan, F Murad, Zanetti Glucia, B M Menna, G Jimborean, E Ianoi, A D Comes, A Ticinesi, F Lauretani, A Nouvenne, Y Sui, J Li, Z Zou, N Nair, L Lewis, T Lakiang, Sun Huaying, Zhou Liping, H Lu, H Rui, Y Pengxin, T Banerjee, A Bhattacharjee, S Upadhyay, M Basu, M Cardenat, K Horo, Amon-Tanoh- Dick, F, Ahmed Sakr, Sherbini Mouhamed   +69 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Three-dimensional imaging and analysis of entire peripheral nerves after repair and reconstruction

, 2017
Christos Bikis, Lucas Degrugillier, Peter Thalmann, G. V. Schulz, Bert Müller, Simone Hieber, Daniel F. Kalbermatten, Srinivas Madduri   +7 more
openalex   +2 more sources

Analysis of Dynamic Brain Imaging Data [PDF]

, 1999
P.P. Mitra, B. Pesaran
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Rethinking Clinical Trials in Age-Related Macular Degeneration: How AI-Based OCT Analysis Can Support Successful Outcomes

Pharmaceuticals
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. Due to an aging population, its prevalence is expected to increase, making novel and optimized therapy options imperative.
Marie Louise Enzendorfer, Merle Tratnig-Frankl, Anna Eidenberger, Johannes Schrittwieser, Lukas Kuchernig, Ursula Schmidt-Erfurth   +5 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source