Results 121 to 130 of about 34,558,744 (307)

MIPAR Spotlight: Shedding Light on Next-Generation Detection for Microscopists [PDF]

BIO Web of Conferences
Nordqvist Sammy, Nordqvist Sammy, Sosa John, Kudlinski Michael   +3 more
doaj   +1 more source

Automated OCT-tailored and same-visit biomarker-targeted microperimetry in geographic atrophy

Scientific Reports
This proof-of-concept study developed and validated an automated, biomarker-targeted, real-time microperimetry (MP) approach for individualized structure-function assessment in geographic atrophy (GA).
Merle Tratnig-Frankl, Lukas Kuchernig, Klaudia Birner, Simon Schürer-Waldheim, Anna Eidenberger, Johannes Schrittwieser, Markus Gumpinger, Georg Faustmann, Magdalena Baratsits, Oliver Leingang, Gregor S. Reiter, Ursula Schmidt-Erfurth   +11 more
doaj   +1 more source

Failing to Reflect Reality: Gaussian Splatting’s Collapse on Non-Lambertian Surfaces

IEEE Open Journal of Signal Processing
We explore the applicability of Gaussian Splatting (GS) to the view synthesis (VS) of non-Lambertian objects. Materials with anisotropic appearance have always been a failure case for VS, until the recent introduction of spherical harmonics promising ...
Eva Dubar, Sarah Dury, Gauthier Lafruit, Daniele Bonatto   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

On the creations of critical points in scale space with applications to medical image analysis [PDF]

, 2001
In order to investigate the deep structure of Gaussian scale space images, one needs to understand the behaviour of spatial critical points under the influence of blurring.
Florack, L.M.J., Kuijper, A, Kuijper, Arjan, Florack, LMJ Luc, Kuijper, A.   +4 more
core   +1 more source

SEM Image

, 2017
This photograph originally appeared in the 2017 Research student photography and image competition held to celebrate National Science Week (18 August - 8 September 2017).
Azam Dolatshah
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source