Results 81 to 90 of about 6,033,773 (285)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Assessing the Impact of Color Normalization in Convolutional Neural Network-Based Nuclei Segmentation Frameworks

Frontiers in Bioengineering and Biotechnology, 2019
Image analysis tools for cancer, such as automatic nuclei segmentation, are impacted by the inherent variation contained in pathology image data. Convolutional neural networks (CNN), demonstrate success in generalizing to variable data, illustrating ...
Justin Tyler Pontalba, Thomas Gwynne-Timothy, Ephraim David, Kiran Jakate, Dimitrios Androutsos, April Khademi   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

ART Neural Networks for Remote Sensing Image Analysis [PDF]

, 1999
ART and ARTMAP neural networks for adaptive recognition and prediction have been applied to a variety of problems, including automatic mapping from remote sensing satellite measurements, parts design retrieval at the Boeing Company, medical database ...
Carpenter, Gail A., Gjaja, Marin N., Gopal, Sucharita, Woodcock, Curtis   +3 more
core   +1 more source

Security Camera Movie and ERP Data Matching System to Prevent Theft

, 2017
In this paper, we propose a SaaS service which prevents shoplifting using image analysis and ERP. In Japan, total damage of shoplifting reaches 450 billion yen. Based on cloud and data analysis technology, we propose a shoplifting prevention service with
Fukumoto, Yoshifumi, Kumazaki, Hiroki, Yamato, Yoji   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Automated Detection and Biomarker Identification Associated with the Structural and Functional Progression of Glaucoma on Longitudinal Color Fundus Images

Applied Sciences
The diagnosis of primary open-angle glaucoma (POAG) progression based on structural imaging such as color fundus photos (CFPs) is challenging due to the limited number of early biomarkers, as commonly determined by clinicians, and the inherent ...
Iyad Majid, Zubin Mishra, Ziyuan Chris Wang, Vikas Chopra, Dale Heuer, Zhihong Jewel Hu   +5 more
doaj   +1 more source

Automated Classification of Glandular Tissue by Statistical Proximity Sampling

International Journal of Biomedical Imaging, 2015
Due to the complexity of biological tissue and variations in staining procedures, features that are based on the explicit extraction of properties from subglandular structures in tissue images may have difficulty generalizing well over an unrestricted ...
Jimmy C. Azar, Martin Simonsson, Ewert Bengtsson, Anders Hast   +3 more
doaj   +1 more source