Results 21 to 30 of about 285,255 (319)

High-throughput detection of DNA double-strand breaks using image cytometry. [PDF]

Biotechniques, 2015
Assessment of γH2AX expression for studying DNA double-strand break formation is often performed by manual counting of foci using immunofluorescence microscopy, an approach that is laborious and subject to significant foci selection bias. Here we present
Fowler TL, Bailey AM, Bednarz BP, Kimple RJ.   +3 more
europepmc   +2 more sources

Psammoma bodies as signs of choroid plexus ageing: A morphometric analysis [PDF]

Vojnosanitetski Pregled, 2017
Background/Aim. Psammoma bodies (PB) are regarded as benign consequences of ageing in choroid plexus stroma. The aim of this study was to assess the morphometric characteristics of psammoma bodies of all four choroid plexuses during the ageing process ...
Živković Vladimir S., Stanojković Milica M., Antić Milorad M.   +2 more
doaj   +1 more source

Comparative assessment of exfoliated gingival cells in healthy individuals and chronic periodontitis patients with and without tobacco chewing habit: A cytomorphometric study

Journal of Indian Society of Periodontology, 2022
Background: Cytomorphometry is the analysis of the morphometry of exfoliated cells. Studies on exfoliated gingival epithelial cells in chronic periodontitis were not evident on the literature search.
Sachita S Naik, Aarati Nayak, Vijaylakshmi Kottrashetti, Akanksha Bhatt   +3 more
doaj   +1 more source

Assessment of ploidy status in oral potentially malignant disorders – A systematic review

Journal of Pharmacy and Bioallied Sciences, 2023
Malignant and potentially malignant epithelial lesions are often associated with various abnormalities such as epithelial dysplasia, abnormal DNA content, loss of heterozygosity, and chromosomal number aberrations.
S Annapoorani, N Gururaj, V Abiraami Balambigai, Nilima Prakash, P Hasinidevi, V Janani   +5 more
doaj   +1 more source

Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments

Journal for ImmunoTherapy of Cancer, 2021
Background The human tumor microenvironment (TME) is a complex and dynamic milieu of diverse acellular and cellular components, creating an immunosuppressive environment, which contributes to tumor progression.
Kunle Odunsi, Hans Minderman, Maulasri Bhatta, Gautam N Shenoy, Jenni L Loyall, Brian D Gray, Meghana Bapardekar, Alexis Conway, Raymond J Kelleher Jr, Beatriz M Carreno, Gerald Linette, Leonard D Shultz, Sathy V Balu-Iyer, Koon Yan Pak, Richard B Bankert   +14 more
doaj   +1 more source

Tumor and immune remodeling following radiotherapy in human renal cell carcinoma

Journal for ImmunoTherapy of Cancer, 2023
Background Studies evaluating peripheral patient samples show radiation can modulate immune responses, yet the biological changes in human tumors particularly at the cellular level remain largely unknown.
Paul K Wallace, Thomas Schwaab, Scott I Abrams, Elizabeth A Repasky, Alexis Conway, Jason B Muhitch, Jacky Chow, Adil Khan, Madeline Gaudieri, Brianna J Wasik, Kah Teong Soh, Anurag K Singh   +11 more
doaj   +1 more source

Genome Size of Life Forms of Araceae—A New Piece in the C-Value Puzzle

Plants, 2022
The genome size of an organism is an important trait that has predictive values applicable to various scientific fields, including ecology. The main source of plant C-values is the Plant DNA C-values database of the Royal Botanic Gardens Kew, which ...
Domen Kocjan, Jasna Dolenc Koce, Florian Etl, Marina Dermastia   +3 more
doaj   +1 more source

Correlative Multi-Modal Microscopy: A Novel Pipeline for Optimizing Fluorescence Microscopy Resolutions in Biological Applications

Cells, 2023
The modern fluorescence microscope is the convergence point of technologies with different performances in terms of statistical sampling, number of simultaneously analyzed signals, and spatial resolution. However, the best results are usually obtained by
Simone Pelicci, Laura Furia, Pier Giuseppe Pelicci, Mario Faretta   +3 more
doaj   +1 more source

Relation of Nuclear Morphometry with Clinicopathologic Prognostic Parameters and Immunohistochemical ER, PR and Cerb-B2 Expressions in Breast Carcinoma

Ahi Evran Medical Journal, 2021
Purpose: Computerized histomorphometric analyses have been widely used as a diagnostic tool for the differential diagnosis of various tumors including breast carcinoma, as well as the grading of malignant tumors and evaluation of prognosis and ...
Murat ÇELİK, Zeliha ÇELİK, Pınar KARABAĞLI, Ceyhan UĞURLUOĞLU , Serdar ALTINAY, Özlem YAVAŞ ATA   +5 more
doaj   +1 more source

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

Cell Reports, 2017
Here, we describe a multiplexed immunohistochemical platform with computational image processing workflows, including image cytometry, enabling simultaneous evaluation of 12 biomarkers in one formalin-fixed paraffin-embedded tissue section.
Takahiro Tsujikawa, Sushil Kumar, Rohan N. Borkar, Vahid Azimi, Guillaume Thibault, Young Hwan Chang, Ariel Balter, Rie Kawashima, Gina Choe, David Sauer, Edward El Rassi, Daniel R. Clayburgh, Molly F. Kulesz-Martin, Eric R. Lutz, Lei Zheng, Elizabeth M. Jaffee, Patrick Leyshock, Adam A. Margolin, Motomi Mori, Joe W. Gray, Paul W. Flint, Lisa M. Coussens   +21 more
doaj   +1 more source