Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Plant-based diets and destination image: A holistic approach [PDF]
A growing number of individuals in contemporary society follow a plant-based diet due to discourse and debates around the environmental impacts, the treatment of animals and health-related issues associated with animal agriculture. At the same time, food
Guachalla, A.
core +1 more source
Testing the role of country and destination image effect on satisfaction and revisit intentions among Western travellers. [PDF]
Image is significant when tourists choose select their destination. Country and destination image are two concepts of image in the tourism industry which are important.
Nimit Soonsan, Prof Sasiwemon Sukahbot
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The Role of Place Attachment as a Mediator Between Destination Image and Revisit Intention
Tourism is one of the sectors that contributes to Indonesia's economic growth. The tourism sector needs to increase the number of tourist visits by improving the good image of visitors so that they are interested in visiting again. Factors that influence
Agung Budiatmo, Sari Listyorini
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Cyprus' image—a sun and sea destination—as a detrimental factor to seasonal fluctuations. Exploration into motivational factors for holidaying in Cyprus [PDF]
Cyprus is established as a summer destination. To aid the destination in developing its winter season as well, this research uses a qualitative inductive approach to explore the tourists’ current image of the island and their motivations of visiting it ...
Koutra, Christina, Karyopouli, S.
core +1 more source
Marketing of a destination: Jordan as a case study [PDF]
This study investigates the internal and external environmental factors that affect destination marketing in Jordan and the use of the destination marketing concept by tourism companies in Jordan.
Alhroot, Abdel-Hafiz Hussein Jaddou
core +4 more sources
In recent years, many has begun to doubt the continued existence of Bali’s nature and culture in shaping its destination image. The current research was conducted to confirm the existence of culture and nature as the determining factors of Bali’s image ...
I Gusti Bagus Rai Utama
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source

