Results 51 to 60 of about 27,431 (257)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A study of cultural distance, eWOM and perceived risk in shaping higher education students' destination image and future travel plan [PDF]

Journal of Tourism Futures
Purpose – This study aims to predict the effect of cultural distance, perceived risk and electronic word of mouth (eWOM) on higher education institutes' students' destination image.
Xia Yang, Jihad Mohammad, Farzana Quoquab   +2 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The Impact of a Local Well-Being Philosophy on Revisit Intentions to Bali Among Digital Nomads

Tourism and Hospitality
The level of success in tourism is gauged by several metrics; however, the most widely used is the level of tourist arrivals. However, this research answered the call for greater investigation of the impacts of qualitative factors and intangible cultural–
Hanugerah Kristiono Liestiandre, Alastair M. Morrison, Ni Nyoman Kerti Yasa, Tjok Gd Raka Sukawati, I. Putu Gde Sukaatmadja   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

ISLANDS AND DESTINATION IMAGE: THE CASE OF IOS [PDF]

, 2007
This study was conducted to identify the image of Ios as a tourist destination as perceived by the visitors, in order to contribute to the formation of an effective marketing plan. The strengths and weaknesses of the image of Ios were measured and presented, accompanied with a number of recommendations.
Stylidis, Dimitrios, Terzidou, Matina, Terzidis, Konstantinos   +2 more
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The lure of siren’s song: Exploring the influence of destination song perception on potential tourists’ travel intentions

PLoS ONE, 2023
Tourism destinations are the important research objects of tourism geography. And destination songs, as a media of tourism destination image, play a very important role in it.
Long Wei, Ting Shao, Xinwei Shi, Keqin Ren, Ying Qian   +4 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Examining the Mediating Effect of Destination Image Between Sensory Impression and Behavioral Intention: Empirical Evidence From China World Natural Heritage Sites

SAGE Open
Destination image and sensory impression are crucial to examine the tourist experience and behavioral intention. However, substantial knowledge gaps exist regarding how sensory impressions affect destination images and their mediating role in behavioral ...
Qiwen Zheng, Suraiyati Rahman
doaj   +1 more source