Results 71 to 80 of about 11,518,650 (280)
The Prentice-O'Gorman destination appraisal matrix: Iranian case study [PDF]
, 2008 Prentice's model was designed to challenge a tendency in contemporary destination marketing to emphasise SSPs (Standardised Selling Points) rather than USPs (Unique (or at least Unusual) Selling Points). This process of standardisation is what the French
O'Gorman, Kevin D., Prentice, Richard
core +3 more sources
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
PLoS ONE, 2023 Tourism destinations are the important research objects of tourism geography. And destination songs, as a media of tourism destination image, play a very important role in it.
Long Wei +4 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
THE ROLE OF RESORT PLANNING IN SUSTAINING TOURIST DESTINATION IMAGE [PDF]
The environmental quality is recognized to be an important factor while making decisions upon the destination to visit. The image of the resort will likely to be more realistic but also complex after the tourists’ visit.
Ozdemir, Gocke
core
SAGE OpenDestination image and sensory impression are crucial to examine the tourist experience and behavioral intention. However, substantial knowledge gaps exist regarding how sensory impressions affect destination images and their mediating role in behavioral ...
Qiwen Zheng, Suraiyati Rahman
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Destination Image and Tourism Satisfaction: The Case of a Mediterranean Destination
Academic Journal of Interdisciplinary Studies, 2014 In tourism industry the competitiveness among tourism destinations has become increasingly demanding. A large number of existing and new destinations are competing to attract tourists in order to enhance their results as well as to gain better position on international tourism market.
openaire +3 more sources