Results 31 to 40 of about 189,563 (212)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Image Watermarking pada Citra Medis menggunakan Compressive Sensing berbasis Stationary Wavelet Transform

Jurnal Elkomika, 2020
ABSTRAK Watermarking pada citra medis dilakukan untuk melindungi hak kepemilikan dan keaslian sebuah citra medis. Proses embedding dan extraction dirancang menggunakan metode Stationary Wavelet Transform (SWT) dan Statistical Mean Manipulation (SMM ...
YASQI HAFIZHANA, IRMA SAFITRI, LEDYA NOVAMIZANTI, NUR IBRAHIM   +3 more
doaj   +1 more source

Effects of image compression on face image manipulation detection: A case study on facial retouching

IET Biometrics, 2021
Numerous methods have been introduced to reliably detect digital face image manipulations in the past. Of late, the generalisability of these schemes has been questioned in particular with respect to image post‐processing.
Christian Rathgeb, Kevin Bernardo, Nathania E. Haryanto, Christoph Busch   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

HarmoDehazeDiffusion: Multi-Scale Spatial Fusion Network for Dense Haze Removal

Applied Sciences
Image dehazing remains a critical yet challenging task in computer vision. While the existing dehazing methods have achieved notable progress, they still struggle to effectively eliminate dense haze in scenes while maintaining consistent illumination ...
Jiangjie Yu, Lina Yang, Shangqing Dai, Haoyan Yang   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Manipulation of Age Variation Using StyleGAN Inversion and Fine-Tuning

IEEE Access, 2023
Recent advancements in deep learning have yielded significant developments in age manipulation techniques in the field of computer vision. To handle this task, recent approaches using generative adversarial networks latent space transformation or image ...
Dongsik Yoon, Jineui Kim, Vincent Lorant, Sungku Kang   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source