Results 51 to 60 of about 12,025,084 (256)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Exposing image forgery through detecting contrast enhancement [PDF]
, 2013 In this paper, a novel forensic method of exposing cut-and-paste image forgery through detecting contrast enhancement is proposed. We reveal the inter-channel correlation introduced by color image interpolation, and show how a linear or nonlinear ...
Hu, Yongjian +2 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The Effect of Manipulation and Mobilisation on Pressure Pain Thresholds in the Thoracic Spine [PDF]
, 2004 High velocity low amplitude (HVLA) thrust manipulation and mobilisation are commonly used by manual therapists to relieve spinal pain and improve mobility. The aim of this controlled, single blinded study was to investigate the effect of manipulation and
Fryer, Gary, Carub, Joanne, McIver, S
core +1 more source
HarmoDehazeDiffusion: Multi-Scale Spatial Fusion Network for Dense Haze Removal
Applied SciencesImage dehazing remains a critical yet challenging task in computer vision. While the existing dehazing methods have achieved notable progress, they still struggle to effectively eliminate dense haze in scenes while maintaining consistent illumination ...
Jiangjie Yu +3 more
doaj +1 more source
Jurnal Elkomika, 2020 ABSTRAK Watermarking pada citra medis dilakukan untuk melindungi hak kepemilikan dan keaslian sebuah citra medis. Proses embedding dan extraction dirancang menggunakan metode Stationary Wavelet Transform (SWT) dan Statistical Mean Manipulation (SMM ...
YASQI HAFIZHANA +3 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Effects of image compression on face image manipulation detection: A case study on facial retouching
IET Biometrics, 2021 Numerous methods have been introduced to reliably detect digital face image manipulations in the past. Of late, the generalisability of these schemes has been questioned in particular with respect to image post‐processing.
Christian Rathgeb +3 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source