Results 191 to 200 of about 263,197 (303)

Developmental Milestones for Children With Down Syndrome: Revised Estimates Using Moving Average Summaries

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Children with Down syndrome follow distinct developmental trajectories that require specialized monitoring and counseling. We aimed to provide updated estimates of developmental milestone attainment using a nonparametric approach and to compare these results with previously reported generalized linear mixed‐effects model (GLMM ...
Rahaf Tarawneh   +4 more
wiley   +1 more source

Effect of confining pressure on fracture characteristics and mineralogical behavior of tight sandstone specimens after hydraulic fracturing

open access: yesDeep Underground Science and Engineering, EarlyView.
Hydraulic fracturing in tight sandstone and fracture propagation characteristics using backscattered electron‐scanning electron microscope (BSE‐SEM) images. Abstract This study focuses on hydraulic fracturing experiments conducted under triaxial conditions on tight sandstone specimens from Shivpuri district, Madhya Pradesh, India.
Pankaj Rawat, Narendra Kumar Samadhiya
wiley   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff   +6 more
wiley   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm   +7 more
wiley   +1 more source

Sub-cone visual acuity can be achieved with less than 1 arcmin retinal slip. [PDF]

open access: yesJ Vis
Lukyanova V   +6 more
europepmc   +1 more source

The role of Rho GTPases in facial morphogenesis

open access: yesDevelopmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

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