Results 221 to 230 of about 11,644,818 (249)

Ionomic and metabolic signatures governing sterility mosaic disease resistance in pigeonpea. [PDF]

Front Plant Sci
Kapoor P, Sharma M, Rao Mediga K, Saini S, Kshirsagar D, Chhabra S.   +5 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Simultaneous 3D structural-functional assessment of pediatric lung using 0.55-T MRI: a feasibility study. [PDF]

Radiol Adv
Miao X, Lee NG, Nguyen HN, Uribe J, Doyle EK, Chun S, Zhao Z, Cui SX, Singhrao K, Rojas GP, Iyer NP, Kato RM, Nayak KS.   +12 more
europepmc   +1 more source

Efficacy of stiripentol, fenfluramine, and their combination on clinical outcomes in Dravet syndrome: A preliminary report

Epilepsia Open, EarlyView.
Abstract Objective Stiripentol and fenfluramine are approved treatments for Dravet syndrome (DS), but real‐world data comparing their effectiveness and combined use remain limited. Our study aims to explore associations between treatment with stiripentol, fenfluramine, and their combination and clinical outcomes in patients with DS.
Paolo Surdi, Marina Trivisano, Mattia Mercier, Nicola Pietrafusa, Angela De Dominicis, Costanza Calabrese, Simona Cappelletti, Nicola Specchio   +7 more
wiley   +1 more source

Surgically Diagnosed Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia in Asymptomatic Patients. [PDF]

Surg Case Rep
Lu C, Matsuura Y, Yang R, Fickel A, Ning G, Sun C.   +5 more
europepmc   +1 more source

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single‐center cohort of 80 patients

Epilepsia Open, EarlyView.
Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Laura Hecher, Mathias Woidy, Franziska Plein, Tatjana Bierhals, Leonie von Elsner, Theresia Herget, Maja Hempel, Fanny Kortüm, Lev Grinstein, Julia V. Cramer, Jessika Johannsen, Jonas Denecke   +11 more
wiley   +1 more source

Mosaic RASopathies: comprehensive genetic and clinicopathological analysis for diagnosis and management. [PDF]

Front Cell Dev Biol
Belysheva T, Nasedkina T, Zelenova E, Semenova V, Semenova N, Sagoyan G, Kletskaya I, Vishnevskaya Y, Sharapova E, Kulikova K, Vlasov P, Botkina A, Belogurova M, Dorofeeva M, Valiev T, Varfolomeeva S.   +15 more
europepmc   +1 more source

Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care

Epilepsia Open, EarlyView.
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley, Peter Widdess‐Walsh, Christine Linehan, Danielle M. Andrade, Norman Delanty, Patrick B. Moloney   +5 more
wiley   +1 more source

Association Between PS-OCT Derived Polarimetric Entropy and RPE Cellular Metrics Measured With Adaptive Optics Imaging in Retinitis Pigmentosa. [PDF]

Invest Ophthalmol Vis Sci
Hiraoka M, Sakai D, Taniguchi M, Totani K, Kimura S, Hirami Y, Mandai M, Takahashi M, Kurimoto Y, Maeda A.   +9 more
europepmc   +1 more source

Automated montaging and contrast stretching of adaptive optics ophthalmoscope images. [PDF]

Biomed Opt Express
Ayubi GA, Kunala K, Dubra A.
europepmc   +1 more source