Results 61 to 70 of about 841,129 (301)

SOFTWARE-ASSISTED IMAGE ANALYSIS FOR IDENTIFICATION AND QUANTIFICATION OF HEPATIC SINUSOIDAL DILATATION AND CENTRILOBULAR FIBROSIS

ABCD: Arquivos Brasileiros de Cirurgia Digestiva
Background: Heart dysfunction and liver disease often coexist because of systemic disorders. Any cause of right ventricular failure may precipitate hepatic congestion and fibrosis.
Douglas Mesadri GEWEHR, Allan Fernando GIOVANINI, Sofia Inez MUNHOZ, Seigo NAGASHIMA, Andressa de Souza BERTOLDI, Ana Cristina Lira SOBRAL, Fernando Bermudez KUBRUSLY, Luiz Fernando KUBRUSLY   +7 more
doaj   +2 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Laypersons’ perception of smile esthetics from different backgrounds

Dental Research Journal
Background: Smile esthetics can be subjective. This study aims to assess the effect of culture/geographic location on judging smile esthetics by comparing the perception of smile characteristics between American laypersons (Western culture) and Iranians (
Fereshteh Najarzadegan, Faezeh Eslamipour   +1 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

XNAT-PIC: Extending XNAT to Preclinical Imaging Centers [PDF]

arXiv, 2021
Molecular imaging generates large volumes of heterogeneous biomedical imagery with an impelling need of guidelines for handling image data. Although several successful solutions have been implemented for human epidemiologic studies, few and limited approaches have been proposed for animal population studies.
arxiv  

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Morphometric analysis of neurons from the marginal and substantia gelatinosa layers of human spinal cord: Classification according to laminar organization [PDF]

Vojnosanitetski Pregled, 2005
The main goal of morphometric analysis of neuronal images, except for getting information about their geometry and dendritic branching patterns, is their classification based on laminar organization.
Milošević Nebojša T., Ristanović Dušan S., Stanković Jovan B., Nedeljkov Vladimir B.   +3 more
doaj   +1 more source

Conventional and Deep-Learning-Based Image Reconstructions of Undersampled K-Space Data of the Lumbar Spine Using Compressed Sensing in MRI: A Comparative Study on 20 Subjects

Diagnostics, 2023
Compressed sensing accelerates magnetic resonance imaging (MRI) acquisition by undersampling of the k-space. Yet, excessive undersampling impairs image quality when using conventional reconstruction techniques.
Philipp Fervers, Charlotte Zaeske, Philip Rauen, Andra-Iza Iuga, Jonathan Kottlors, Thorsten Persigehl, Kristina Sonnabend, Kilian Weiss, Grischa Bratke   +8 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source