Results 201 to 210 of about 3,593,039 (336)
Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceHippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà +11 morewiley +1 more sourceTransperineal Implementation of Biocompatible Balloon in Patients Treated With Radiotherapy for Prostate Carcinoma: Feasibility and Quality Assurance Study in Terms of Anatomical Stabilization Using Image Registration Techniques
, 2013 Asimakopoulos, Pantelakos, Kelekis, S Hummel, E Simpson, P Hemingway, M Stevenson, A Rees, M Zelefsky, Z Fuks, L Happersett, H Lee, C Ling, M Zelefsky, Z Fuks, M Hunt, H Lee, D Lombardi, Z Alicikus, Y Yamada, Z Zhang, Pei Hunt, M, A Pollack, A Hanlon, E Horwitz, S Feigenberg, R Uzzo, M Zelefsky, E Levin, M Hunt, Y Yamada, A Shippy, A Wilkins, C Parker, Y Levy, A Paz, R Yosef, B Corn, B Vaisman, R Ben-Yosef, Paz Levy, Y Alani, S Muncher, Y, L Livi, B Detti, M Meattini, L Sanchez, G Biti, J Ryu, K Winter, J Michalski, J Purdy, A Markoe, J Michalski, K Winter, J Purdy, M Parliament, H Wong, I Kantzou, K Platoni, P Sandilos, A Gouliamos, I Kouvaris, C Lawton, J Michalski, I El-Naqa, M Buyyounouski, W Lee, S Bentzen, L Constine, J Deasy, A Eisbruch, A Jackson, K Rohr, V Markaki, P Asvestas, G Matsopoulos, L Ingber, B Rosen, F Bookstein, C Beard, P Kijewski, M Bussire, R Gelman, D Gladstone, J Antolak, I Rosen, C Childress, G Zagars, A Pollack, L Dawson, K Mah, E Franssen, G Morton, A D'amico, J Manola, M Loffredo, L Lopes +99 moreopenalex +1 more sourceEnhanced muscle MRI using deep learning: shorter acquisition time with improved image quality. [PDF]
PeerJFan P, Zhang Z, Hou B, Liu D, Nickel MD, Zhu J, Dai Y, Wang Q, Wang F, Yu W, Feng F. +10 moreeuropepmc +1 more sourceDeciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall +14 morewiley +1 more source