Results 91 to 100 of about 34,223 (259)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Image encryption and distribution method based on LFSR and counters

open access: yesÌнформаційні технології та компʼютерна інженерія
In the conditions of processing large amounts of graphic data, the task arises of developing a reliable image encryption scheme with reduced computing costs.
V. Luzhetsky, M. Tsikhotskyi
doaj   +1 more source

Image Authentication under DCT Domain with Attack Recovery

open access: yes, 2013
Image authentication schemes verify the integrity of an image against malicious manipulations. Most image authentication methods treat all manipulations as attacks.
Chen, Chien Chang; Ke, Husan An
core  

Curl-Constrained Gradient Estimation for Image Recovery from Highly Incomplete Spectral Data [PDF]

open access: yes, 2017
In this paper, we introduce new gradient-based methods for image recovery from a small collection of spectral coefficients of the Fourier transform, which is of particular interest for several scanning technologies, such as magnetic resonance imaging ...
Ravazzi, Chiara   +5 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Investigation of a new method for improving image resolution for camera tracking applications

open access: yes, 2015
Camera based systems have been a preferred choice in many motion tracking applications due to the ease of installation and the ability to work in unprepared environments.
Longstaff, Andrew P.   +4 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Sparse Recovery Algorithm for Compressed Sensing Using Smoothed l0 Norm and Randomized Coordinate Descent

open access: yesMathematics, 2019
Compressed sensing theory is widely used in the field of fault signal diagnosis and image processing. Sparse recovery is one of the core concepts of this theory.
Dingfei Jin   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

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