Results 211 to 220 of about 12,985,730 (296)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Enhanced image annotations based on spatial information extraction and ontologies
Current research on image annotation often represents images in terms of labelled regions or objects, but pays little attention to the spatial positions or relationships between those regions or objects.
Payne, Terry R. +3 more
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Ultrasound Image Representation Learning by Modeling Sonographer Visual Attention. [PDF]
Inf Process Med Imaging, 2019 Droste R +6 more
europepmc +1 more source
Image Representations for Pattern Recognition.
, 2011 One of the main requirements in many signal processing applications is to have a "meaningful representation'' in which signal's characteristics are readily apparent. For example, for recognition, the representation should highlight salient features; for denoising, it should efficiently separate signal and noise; and for compression, it should capture a
openaire +2 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
A Hybrid Geometric Spatial Image Representation for scene classification. [PDF]
PLoS One, 2018 Ali N +7 more
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Computer-aided detection and visualization of pulmonary embolism using a novel, compact, and discriminative image representation. [PDF]
Med Image Anal, 2019 Tajbakhsh N +3 more
europepmc +1 more source