Results 31 to 40 of about 93,063 (265)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

LINGUISTIC MEANS OF REPRODUCING IMPLIED SENSE IN THE TRANSLATION OF R. FROST’S POETRY [PDF]

open access: yesAlfred Nobel University Journal of Philology
This article aims to identify poetic implied sense markers in the original poetry of American poet Rob- ert Frost and means of their reproduction in translation, in particular, translation transformations. Among the methods applied in this study is the
Valeriy M. Kykot
doaj   +1 more source

Image Classification and Optimized Image Reproduction

open access: yesCoRR, 2012
5 Pages, 9 ...
Jaswinder Singh Dilawari   +1 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Image-quality metric system for color filter array evaluation.

open access: yesPLoS ONE, 2020
A modern color filter array (CFA) output is rendered into the final output image using a demosaicing algorithm. During this process, the rendered image is affected by optical and carrier cross talk of the CFA pattern and demosaicing algorithm.
Tae Wuk Bae
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

In vitro Study of Biological Properties of SARS-CoV-2 Coronavirus Strains Related to Various Genetic Variants

open access: yesПроблемы особо опасных инфекций, 2022
The aim of the research was to study reproduction features of SARS-CoV-2 coronavirus strains of various genetic lines on Vero and Vero E6 cell culture.Materials and methods.
A. V. Zaykovskaya   +6 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Dynamic Range Compression of Infrared Images Based on Histogram Equalization with Edge Inversion

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники
The problem of compression of the dynamic range of infrared images is considered. To improve the quality of tone mapping of infrared images when their dynamic range is compressed and to simplify the control over the reproduction characteristics of ...
S. I. Rudikov   +2 more
doaj   +1 more source

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