Results 121 to 130 of about 2,604,798 (327)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A joint image super‐resolution network for multiple degradations removal via complementary transformer and convolutional neural network

IET Image Processing
While recent years have witnessed the unprecedented success of deep convolutional neural networks (CNNs) and vision transformers in single‐image super‐resolution (SISR), the degradation assumptions are simple and usually bicubic downsampling. Thus, their
Guoping Li, Zhenting Zhou, Guozhong Wang
doaj   +1 more source

Topology Optimization-Based Localized Bone Microstructure Reconstruction for Image Resolution Enhancement: Accuracy and Efficiency. [PDF]

Bioengineering (Basel), 2022
Kim J, Kim JJ.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Continuum finite element analysis generalizes<i>in vivo</i>trabecular bone microstructural strength measures between two CT scanners with different image resolution. [PDF]

Biomed Phys Eng Express, 2023
Guha I, Zhang X, Nadeem SA, Levy SM, Saha PK.   +4 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Improvement of image resolution by combining enhanced confocal microscopy and quantum dot triexciton imaging. [PDF]

FEBS Open Bio, 2021
Hennig S, Manstein DJ.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Simultaneous single image super‐resolution and blind Gaussian denoising via slim ghost full‐frequency residual blocks

IET Image Processing
Given that super‐resolution (SR) aims to recover lost information, and low‐resolution (LR) images in real‐world conditions might be corrupted with multiple degradations, considering basic bicubic down‐sampling as the sole degradation significantly limits
Saghar Farhangfar, Aryaz Baradarani, Mohammad Asadpour, Mohammad Ali Balafar, Roman Gr. Maev   +4 more
doaj   +1 more source

The impact of image resolution on power, bias, and confounding: A simulation study of ambient light at night exposure. [PDF]

Environ Epidemiol, 2021
McIsaac MA, Sanders E, Kuester T, Aronson KJ, Kyba CCM.   +4 more
europepmc   +1 more source