Results 101 to 110 of about 11,514,111 (239)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Multifractal imaging filtering and decomposition methods in space, Fourier frequency, and eigen domains [PDF]

Nonlinear Processes in Geophysics, 2007
The patterns shown on two-dimensional images (fields) used in geosciences reflect the end products of geo-processes that occurred on the surface and in the subsurface of the Earth.
Qiuming Cheng
doaj  

Knotting and unknotting of phase singularities: Helmholtz waves, paraxial waves and waves in 2+1 spacetime

, 2001
As a parameter a is varied, the topology of nodal lines of complex scalar waves in space (i.e. their dislocations, phase singularities or vortices) can change according to a structurally stable reconnection process involving local hyperbolas whose ...
Dennis, MR, Berry, MV, Dennis, M.R., Berry, M V, Dennis, M R; id_orcid, Berry, M.V.   +5 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Briançon-Skoda theorem for pseudo-rational and Du Bois singularities and uniformity in excellent rings

Forum of Mathematics, Pi
Suppose J=(f1,…,fn) $J = (f_1, \dots , f_n)$ upper J equals left parenthesis f 1 comma ellipsis comma f Subscript n Baseline right parenthesis is an n-generated ideal in any ring R.
Linquan Ma, Peter M. McDonald, Rebecca R.G., Karl Schwede   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

CURIOSIDADES COLONIALES EN LETRA Y TRAZO: UNA PROYECCIÓN MUNDIALIZADORA

Revista Chilena de Literatura, 2007
La construcción de lo Otro como una forma de mundialización a través de textos y grabados sobre América colonial. Los textos sobre Brasil en el siglo XVI y XVII son retratos que forman parte de una colección. La divulgación de estos artefactos conforman,
Clicie Nunes A
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Weakly exceptional quotient singularities [PDF]

, 2013
A singularity is said to be weakly-exceptional if it has a unique purely log terminal blow up. In dimension 2, V. Shokurov proved that weakly exceptional quotient singularities are exactly those of types Dn, E6, E7, E8.
Sakovics, Dmitrijs
core   +1 more source