Results 121 to 130 of about 14,589,261 (282)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Optimization Method for Controllable Image Style Transfer Based on DDPM Guided by Cross-Modal Text

IEEE Access
Traditional image style transfer methods rely mostly on a single image modal. Although they can introduce style features, it is difficult to achieve high-level semantic consistency while maintaining the content structure.
Shengnan Ding, Yufeng Shi
doaj   +1 more source

Edge Enhanced Image Style Transfer via Transformers

, 2023
In recent years, arbitrary image style transfer has attracted more and more attention. Given a pair of content and style images, a stylized one is hoped that retains the content from the former while catching style patterns from the latter.
Yang, Jun, Dai, Zaiyan, Zhang, Chiyu, Cao, Peng   +3 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

RECDFS: Rotation Equivariant Convolution and Delayed Feature Statistics for arbitrary neural style transfer

Journal of King Saud University: Computer and Information Sciences
The aim of arbitrary style transfer is to render an image with the style of a reference image while preserving the original content. A key challenge is the extracting and maintaining global image information due to the local nature of convolutional ...
Ya-Qi Sun, Jin Xiang, Paul L. Rosin, Yu-Kun Lai, Hui-Huang Zhao, Zhi Li, Xiao-Lan Xie   +6 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

A Generative Adversarial Network AMS-CycleGAN for Multi-Style Image Transformation

IEEE Access
The objective of image style transfer is to create an image that has the artistic features of a reference style image while also retaining the details of the original content image.
Xiaodi Rang, Zhengyu Dong, Jiachen Han, Chaoqing Ma, Guangzhi Zhao, Wenchao Zhang   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

nucleAIzer: A Parameter-free Deep Learning Framework for Nucleus Segmentation Using Image Style Transfer. [PDF]

Cell Syst, 2020
Hollandi R, Szkalisity A, Toth T, Tasnadi E, Molnar C, Mathe B, Grexa I, Molnar J, Balind A, Gorbe M, Kovacs M, Migh E, Goodman A, Balassa T, Koos K, Wang W, Caicedo JC, Bara N, Kovacs F, Paavolainen L, Danka T, Kriston A, Carpenter AE, Smith K, Horvath P.   +24 more
europepmc   +1 more source