Results 131 to 140 of about 621,417 (312)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
A Modular Percussion Synthesis Environment
, 2010 The construction of new virtual instruments is one long-term goal of physical modeling synthesis; a common strategy across various different physical modeling methodologies, including lumped network models, modal synthesis and scattering based methods ...
Bilbao, Stefan
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Unsupervised image segmentation combining region and boundary estimation [PDF]
An integrated approach to image segmentation is presented that combines region and boundary information using maximum a posteriori estimation and decision theory.
Bhalerao, Abhir, Wilson, Roland
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
HDR image synthesis based on multi-exposure color images
, 2011 In digital camera, it's difficult to exceed the dynamic range of 60~80dB because of the saturation current and background noise of CCD/CMOS image sensor in a single exposure image.
WangHua +4 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Cycle-consistent diverse image synthesis from natural language
, 2019 Text-to-image translation has become an attractive yet challenging task in computer vision. Previous approaches tend to generate similar, or even monotonous, images for distinctive texts and overlook the characteristics of specific sentences.
Chen, Zhi +3 more
core +1 more source
Recovery-Based Occluded Face Recognition by Identity-Guided Inpainting
SensorsOcclusion in facial photos poses a significant challenge for machine detection and recognition. Consequently, occluded face recognition for camera-captured images has emerged as a prominent and widely discussed topic in computer vision.
Honglei Li +4 more
doaj +1 more source