Results 191 to 200 of about 1,203,914 (376)

Memory and Imagination: Epistemological Perspectives from British Empiricists to Neuroscience

, 2016
Tzofit Ofengenden
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

From Whiskey Rebellion to Donald Trump and the Question of Power. An Interview with Isaac Ariail Reed

Sociální studia, 2017
The Imagination Collectif
doaj  

Notes from Self-Isolation: Imagination in Times of Ruptures. [PDF]

Integr Psychol Behav Sci
Hawlina H, Zittoun T.
europepmc   +1 more source

INTUSSUSCEPTION IN ADULTS DUE TO THE IMAGINATION OF A MECKELʼS DIVERTICULUM

, 1925
William E. Lower
openalex   +2 more sources

Picturing the Autobiographical Imagination: Emotion, Memory and Metacognition inInside Out

, 2021
Wyatt Moss-Wellington
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Reimagining open science for global health: Epistemic power and the pursuit of health equity. [PDF]

PLOS Glob Public Health
Rangel Teixeira A, Kleinlein R, Kalema NL, Agyemang GO, Senteio C, Celi LA, Agyemang S, Kebede MA.   +7 more
europepmc   +1 more source

Publication : "Baroque Antiquity. Archaeological Imagination in Early Modern Europe".

, 2016
Maxime Georges Métraux
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source