Results 111 to 120 of about 3,026,631 (352)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Freehand Scanning for Precordial Data Acquisition in Three-Dimensional Echocardiography [PDF]

, 2022
S.31-35Computer-based three-dimensional (3D) visualisation of the heart is an important step forward towards improved analysis of complex cardiac structures and reliable quantification of volumes.
Grimm, M., Sakas, G., Richtscheid, M.
core  

Prediction Of Suitable Lip Support With Nasolabial Angle Edentulous Patients

International Dental Journal
Aim or purpose: The present investigation aims to investigate the correlation between lip fullness and lip support and to explore a virtual prediction method for suitable lip support in Chinese edentulous patients Materials and methods: A series of ...
You Lang
doaj   +1 more source

Application value of computed tomography and magnetic resonance imaging three-dimensional reconstruction and digital subtraction angiography in percutaneous transhepatic cholangial drainage. [PDF]

Front Surg, 2022
Zhou SL, Ji TJ, Zhou XY, Xu L, Xin Y, Huang QJ.   +5 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

The multi-modality cardiac imaging approach to the Athlete's heart: an expert consensus of the European Association of Cardiovascular Imaging [PDF]

, 2015
peer reviewedThe term 'athlete's heart' refers to a clinical picture characterized by a slow heart rate and enlargement of the heart. A multi-modality imaging approach to the athlete's heart aims to differentiate physiological changes due to intensive ...
Galderisi, Maurizio, Popescu, Bogdan A., Cosyns, B, Petersen, SE, Cardim, Nuno, DAVIN, Laurent, Schroeder, S, Kitsiou, Anastasia, Cosyns, Bernard, Lancellotti, Patrizio, Petersen, Steffen E., Habib, G, Kitsiou, A, Edvardsen, T, Davin, L, Cardim, N, Bruder, Oliver, Popescu, Bogdan Alexandru, Burgstahler, C, D'Andrea, Antonello, Donal, E, Bruder, O, Plein, S, Freitas, A, Freitas, Antonio, Burgstahler, Christof, Galderisi, M, Edvardsen, Thor, Donal, Erwan, Lancellotti, P, Plein, Sven, D'Andrea, A, Schroeder, Stephen, Habib, Gilbert, Popescu, BA   +34 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Residual flatness error correction in three-dimensional imaging confocal microscopes [PDF]

, 2018
Imaging Confocal Microscopes (ICM) are highly used for the assessment of three-dimensional measurement of technical surfaces. The benefit of an ICM in comparison to an interferometer is the use of high numerical aperture microscope objectives, which ...
Bermúdez, Carlos, Matilla Sánchez, Aitor, Cadevall Artigues, Cristina, Felgner, André, Martínez Marín, Pol, Artigas Pursals, Roger   +5 more
core   +1 more source

Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues

Nature Biotechnology, 2016
The biology of multicellular organisms is coordinated across multiple size scales, from the subnanoscale of molecules to the macroscale, tissue-wide interconnectivity of cell populations.
T. Ku, Justin Swaney, Jeong-Yoon Park, Alexandre Albanese, Evan Murray, J. H. Cho, Young-Gyun Park, Vamsi Mangena, Jiapei Chen, Kwanghun Chung   +9 more
semanticscholar   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source