Results 121 to 130 of about 14,314,474 (297)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

3D stereophotogrammetry facial analysis of Angle I subjects: gender comparison

Revista de Odontologia da UNESP
Objective The aim of this study was to establish reference parameters for facial analysis in subjects with Angle’s Class I occlusion by means of stereophotogrammetry, comparing men and women. Material and method Twenty-six healthy young adults with Angle’
Ana Maria Bettoni Rodrigues da Silva, Laís Valencise Magri, Álvaro Augusto Junqueira Júnior, Marco Antônio Moreira Rodrigues da Silva   +3 more
doaj   +1 more source

Imaging Three-Dimensional Elemental Inhomogeneity in Pt-Ni Nanoparticles Using Spectroscopic Single Particle Reconstruction. [PDF]

Nano Lett, 2019
Wang YC, Slater TJA, Leteba GM, Roseman AM, Race CP, Young NP, Kirkland AI, Lang CI, Haigh SJ.   +8 more
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Three-dimensional imaging assisted segmentectomy in the treatment of localized bronchiectasis: a retrospective analysis

Journal of Cardiothoracic Surgery
Background Surgical treatment is crucial in managing bronchiectasis. Segmentectomy, although a complex procedure, has become more feasible with advancements in thin-slice CT and three-dimensional imaging.
Zhiwei Yan, Jian Feng, Xinyu Zhu, Ziqing Shen, Jun Zhao, Jinfeng Ge   +5 more
doaj   +1 more source

Imaging three-dimensional innervation zone distribution in muscles from M-wave recordings. [PDF]

J Neural Eng, 2017
Zhang C, Peng Y, Liu Y, Li S, Zhou P, Rymer WZ, Zhang Y.   +6 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Three Dimensional Medical Imaging: From Dream to Reality

Pediatrics and Neonatology, 2010
Hsu-Yi Chen, Shyh-Jye Chen
doaj   +1 more source