Results 141 to 150 of about 5,078,706 (298)

Quantitative Imaging [PDF]

Investigative Radiology, 2015
Alkadhi, Hatem, Frauenfelder, Thomas, Andreisek, Gustav, Boss, Andreas   +3 more
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

What Comes First? Multitissue Involvement Leading to Radiographic Osteoarthritis: Magnetic Resonance Imaging–Based Trajectory Analysis Over Four Years in the Osteoarthritis Initiative

, 2015
Frank W. Roemer, C. Kent Kwoh, Michael J. Hannon, David J. Hunter, F. Eckstein, Tomoko Fujii, Robert M. Boudreau, Ali Guermazi   +7 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Pyrene-Conjugated, 2-Pyridinecarboxaldehyde Derivatives as N-Terminus-Specific Tags for MALDI- and LALDI-MS. [PDF]

Rapid Commun Mass Spectrom
Li MJ, Kucukdisli M, Braun F, Will DW, Meier N, Wehrle B, Meyer LC, Föll MC, Schilling O.   +8 more
europepmc   +1 more source

Neonatal Magnetic Resonance Imaging Pattern of Brain Injury as a Biomarker of Childhood Outcomes following a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy

, 2015
Seetha Shankaran, Scott A. McDonald, Abbot R. Laptook, Susan R. Hintz, Patrick D. Barnes, Abhik Das, Athina Pappas, Rosemary D. Higgins, Abhik Das, Scott A. McDonald, Seetha Shankaran, Richard A. Ehrenkranz, Ronald N. Goldberg, Abbot R. Laptook, Jon E. Tyson, Michele C. Walsh, Abhik Das, Rosemary D. Higgins, Ellen C. Hale, Karen Johnson, Seetha Shankaran, Richard A. Ehrenkranz, Susan R. Hintz, Athina Pappas, Jon E. Tyson, Betty R. Vohr, Kimberly Yolton, Abhik Das, Rosemary D. Higgins, Rebecca Bara   +29 more
openalex   +1 more source

Comparison of Eight Methods for the Estimation of the Image-Derived Input Function in Dynamic [¹⁸F]-FDG PET Human Brain Studies [PDF]

, 2009
Paolo Zanotti‐Fregonara, El Mostafa Fadaili, Renaud Maroy, Claude Comtat, Antoine Souloumiac, Sébastien Jan, Maria-Joao Ribeiro, Véronique Gaura, Avner Bar‐Hen, R. Trébossen   +9 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Body image in recently diagnosed young women with early breast cancer

, 2012
Shoshana M. Rosenberg, Rulla M. Tamimi, Shari Gelber, Kathryn J. Ruddy, Sandra Kereakoglow, Virginia F. Borges, Steven E. Come, Lidia Schapira, Eric P. Winer, Ann H. Partridge   +9 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source