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Neurosurgery Clinics of North America, 2022
In recent years, the hunt for objective biomarkers in chronic pain has intensified, as interest has grown in precision medicine techniques, and the global opioid crisis has underscored the need to accelerate the pace of pain research. A growing body of neuroimaging literature suggests that chronic pain is associated with various alterations in regional
Alon, Kashanian +4 more
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In recent years, the hunt for objective biomarkers in chronic pain has intensified, as interest has grown in precision medicine techniques, and the global opioid crisis has underscored the need to accelerate the pace of pain research. A growing body of neuroimaging literature suggests that chronic pain is associated with various alterations in regional
Alon, Kashanian +4 more
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Imaging biomarkers in tauopathies
Parkinsonism & Related Disorders, 2016Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid cognitive dysfunction and neuron loss.
Dani, Melanie +2 more
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Relevance of plasma biomarkers to imaging biomarkers
Alzheimer's & Dementia, 2023AbstractBackgroundRecent advances in blood‐based biomarkers have shown promising abilities to estimate brain pathological statuses related to amyloid‐β (Aβ) deposition, phosphorylated tau deposition, and neurodegeneration using minimally invasive methods.
Akinori Nakamura +9 more
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Survey of Ophthalmology, 2019
The choroid is the vascular coat of the eye, and its role has been studied in multiple chorioretinal disorders. Recent advancements in choroidal imaging techniques, including enhanced depth imaging optical coherence tomography, swept source optical coherence tomography, en face optical coherence tomography, and optical coherence tomography angiography ...
Sumit Randhir Singh +4 more
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The choroid is the vascular coat of the eye, and its role has been studied in multiple chorioretinal disorders. Recent advancements in choroidal imaging techniques, including enhanced depth imaging optical coherence tomography, swept source optical coherence tomography, en face optical coherence tomography, and optical coherence tomography angiography ...
Sumit Randhir Singh +4 more
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Imaging Biomarkers of Atherosclerosis
Biomarkers in Medicine, 2008Atherosclerosis imaging plays a significant role in an understanding of the natural history of vascular disease and is increasingly used to assess the efficacy of novel therapeutics. Furthermore, the concepts of 'vulnerable plaque' and, more recently, of 'vulnerable patient' have driven cardiovascular imaging technologies to develop methods for ...
Stéphane, Noble +2 more
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Biomarkers in abdominal imaging
Abdominal Imaging, 2008Imaging biomarkers are parameters measurable with imaging methods used to detect, stage or grade disease or assess the response to treatment. Compared with biochemical or histological markers, imaging biomarkers have the advantage of remaining non-invasive and being spatially and temporally resolved.
Bernard E, Van Beers, Valérie, Vilgrain
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Imaging biomarkers, quantitative imaging, and bioengineering
Radiología (English Edition), 2012Imaging biomarkers define objective characteristics extracted from medical images that are related to normal biological processes, diseases, or the response to treatment. To develop an imaging biomarker, it is necessary to carry out a series of steps to validate its relation with the reality studied and to check its clinical and technical validity ...
L, Martí Bonmatí +6 more
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The promise of imaging biomarkers
Drug News & Perspectives, 2010In this white paper, Thomson Reuters provides a snapshot of the imaging biomarkers at use in research and development, and the clinic; examines key technical and commercialization challenges; and identifies promising avenues for progress in the field with insight from experts from industry and academia.
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Imaging Biomarkers of Osteoarthritis
Seminars in Musculoskeletal RadiologyAbstractCurrently no disease-modifying osteoarthritis drug has been approved for the treatment of osteoarthritis (OA) that can reverse, hold, or slow the progression of structural damage of OA-affected joints. The reasons for failure are manifold and include the heterogeneity of structural disease of the OA joint at trial inclusion, and the sensitivity
Frank W. Roemer +7 more
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