Results 91 to 100 of about 12,757,506 (313)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Advanced Concepts for Ultra-Wide-Swath SAR Imaging [PDF]

, 2008
This paper reviews advanced multi-channel SAR system concepts for the imaging of ultra-wide swaths with high azimuth resolution. Novel system architectures and operational modes are introduced and compared to each other with regard to their ...
Patyuchenko, Anton, Bordoni, Federica, Moreira, Alberto, Younis, Marwan, Gebert, Nicolas, Krieger, Gerhard   +5 more
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Effect of Imaging Range on Performance of Terahertz Coded-Aperture Imaging

This paper reveals a counterintuitive, non-monotonic dependence of terahertz coded-aperture imaging (TCAI) performance on the imaging range. This phenomenon stems from phase-induced spatiotemporal correlations in the reference-signal matrix (RSM ...
Yan Teng, Yanchao Shi, Haodong Yang, Xinhong Cui, Xiaoze Li   +4 more
core   +1 more source

Advanced MR Imaging of the Pancreas

, 2020
MR imaging can be optimized to evaluate a spectrum of pancreatic disorders with advanced sequences aimed to provide quantitative results and increase MR diagnostic capabilities.
Hill, Danielle V., Tirkes, Temel
core   +1 more source

Measuring eccentric hamstring strength in senior athletes: reference values, age and sex associations, and limb asymmetry

Frontiers in Sports and Active Living
BackgroundParticipation in Masters sport has increased; however, reference eccentric hamstring strength values are unavailable. Instrumented Nordic hamstring exercise (NHE) testing is used in younger athletes, but reports for senior athletes are lacking ...
Lee J. Hinkle, Lee J. Hinkle, James D. Mead, Emma A. Merrill, Joshua K. Sponbeck, Ron Hager, Ron Hager, A. Wayne Johnson, A. Wayne Johnson   +8 more
doaj   +1 more source

An Individual Finger Gesture Recognition System Based on Motion-Intent Analysis Using Mechanomyogram Signal

Frontiers in Neurology, 2017
Motion-intent-based finger gesture recognition systems are crucial for many applications such as prosthesis control, sign language recognition, wearable rehabilitation system, and human–computer interaction.
Huijun Ding, Qing He, Yongjin Zhou, Guo Dan, Guo Dan, Song Cui   +5 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy

Nature Communications, 2019
The success of radiotherapy relies on tumor-specific delivery of radiosensitizers to attenuate hypoxia resistance. Here we report an ammonia-assisted hot water etching strategy for the generic synthesis of a library of small-sized (sub-50 nm) hollow ...
Wenpei Fan, Nan Lu, Zheyu Shen, Wei Tang, Bo Shen, Zhaowen Cui, Lingling Shan, Zhen Yang, Zhantong Wang, Orit Jacobson, Zijian Zhou, Yijing Liu, Ping Hu, Weijing Yang, Jibin Song, Yang Zhang, Liwen Zhang, Niveen M. Khashab, Maria A. Aronova, Guangming Lu, Xiaoyuan Chen   +20 more
doaj   +1 more source