Results 101 to 110 of about 12,757,506 (313)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The reliability and discriminant validity of physical, technical, and perceptual-physiological measures during a game-specific basketball activity simulation protocol

Frontiers in Psychology
Activity simulation protocols offer useful applications in research and practice; however, the specificity of such protocols to basketball game-play is currently lacking.
Davide Ferioli, Pedro E. Alcaraz, Pedro E. Alcaraz, Tomás T. Freitas, Tomás T. Freitas, Tomás T. Freitas, Tomás T. Freitas, Fabio Trimarchi, Daniele Conte, Lorenzo Formica, Linda H. Chung, Aaron T. Scanlan   +11 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Advances in Cardiovascular Imaging: A Platform to Share Recent Research Findings Through Utilization of Advanced Imaging Technologies

Clinical diagnosis of cardiovascular disease has undergone revolutionary changes over the last decades thanks to rapid developments in medical imaging modalities significantly enhancing the diagnostic performance of cardiac imaging in cardiovascular ...
Zhonghua Sun
core   +1 more source

Machine Learning-Enhanced Architecture Model for Integrated and FHIR-Based Health Data

Information
The widespread fragmentation of patient information across heterogeneous systems and the lack of standardized integration mechanisms hinder efficient and comprehensive medical diagnostics.
Nadia Brancati, Teresa Conte, Simona De Pietro, Martina Russo, Mario Sicuranza   +4 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Clustering analysis of hamstring injuries—A pilot study to determine phenogroups based on injury characteristics and recovery duration

Journal of Experimental Orthopaedics
Purpose The objective of this pilot study was to determine clinically relevant phenogroups of professional football players with hamstring injuries using unsupervised cluster analysis based on demographic and injury‐related characteristics, and to assess
Bálint Zsidai, György Gulácsi, Tibor Rudisch, Bence Márk Kovács, Pete Friar, Richard Nagy, Robert de Jonge, Eric Hamrin Senorski, Kristian Samuelsson, Gergely Pánics   +9 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Evaluation of the effect of hemodynamic factors on retinal microcirculation by using 3D confocal image-based computational fluid dynamics

Frontiers in Bioengineering and Biotechnology
PurposeTo investigate local hemodynamic changes resulting from elevated intraocular pressure (IOP) in different vasculature networks using a computational fluid dynamics model based on 3D reconstructed confocal microscopic images.MethodsThree-dimensional
Chi Wei Ong, Bingyao Tan, Bingyao Tan, Shaista Hussain, Thanadet Chuangsuwanich, Fabian Albert Braeu, Fangsen Cui, Fangsen Cui   +7 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source